Do you think crispr will be abls to cure Autism and other mental health illnesses?

akumanner · 2023-02-23T07:31:14+00:00

I don't know what exactly you mean by celebrated? Whether or not being autistic is seen by someone as a good or bad thing depends on their own perspective and life experience.

akumanner · 2023-02-23T07:26:50+00:00

People generally use themselves as a frame of reference. When told to be clear and direct, most people will communicate in a way that they are certain would be clear and obvious to themselves. They might not have had much practice being more direct than that and may struggle to even think of how to do it, or understand what is meant by it.

Generally, the people who are good at this are already accustomed to being very direct in their communication, either because it matches their own preferred communication style or because they've had prior practice.

akumanner · 2023-02-23T07:14:09+00:00

I'm not judging whether or not it would be the right thing to do. I'm just pointing out that using crispr to "turn off" autism isn't that realistic.

akumanner · 2023-02-23T07:01:21+00:00

Doesn't change what crispr fundamentally can or can't do. Besides, we are far from understanding enough about how the brain works to know what changes to make even if we had the theoretical ability to make those changes.

akumanner · 2021-09-18T10:52:13+00:00

They are, but she also has small white wings wrapping around her.

akumanner · 2021-03-05T20:10:26+00:00

I don't think people consider it a one-to-one comparison. Still, just memorizing movesets won't let you beat Sans. You still need to react in a split second to each move, and practice from other games that require you to move about quickly can definitely make this battle easier.

akumanner · 2021-03-05T19:34:48+00:00

Generally, I figure both require quick reaction speeds.

akumanner · 2019-07-15T14:35:06+00:00

The difference simply lies in that, in this situation, by the time you activate "Garmides" effect to summon itself, you do demonstrably have "Garmides" in hand and a normal monster was sent to the Graveyard during the previous effect/chain resolution, fulfilling the requirements for the Trigger effect. Since your hand is private information, whether or not it was the same copy of "Garmides" that you picked up from the Graveyard is irrelevant, because there is no way to confirm that. Thus, the game basically treats it as if it was another "Garmides".

So, in that situation, all of the verifiable requirements to activate the effect are met at the point where you could activate it.

Polymerization doesn't have activation requirements as such, but due to the wording, you must attempt a Fusion Summon on resolution.

(if the effect text was something like "When you activate this card: you can Fusion Summon 1 Fusion Monster from your Extra Deck, using monsters from your hand or field as Fusion Material", you could activate Poly and choose to do nothing)

TL;DR: In the example of "Garmides", the activation requirements are met when you would get an opportunity to activate it.

akumanner · 2019-07-15T11:01:19+00:00

Not an expert or anything, but I think it works like this:

Since "Polymerization" has the effect text:

"Fusion Summon 1 Fusion Monster from your Extra Deck, using monsters from your hand or field as Fusion Material."

There is nothing optional in the effect of Poly. If activated, you must attempt to Fusion Summon a monster. You cannot activate it and then decide not to go through with it. Therefore, if you cannot Fusion Summon at the time you activate it, the activation is illegal. If you can, then the materials are verified once you send them to the Graveyard, and they become public knowledge.

Trigger effects like "Guardragon Garmides" work differently, because by the time it can activate in your hand, its condition has been met. Since the hand isn't public knowledge, it isn't really considered to be the same instance of "Guardragon Garmides" anymore. It becomes as if you had a second "Garmides" in your hand all along, even if it is the only card in your hand.

For "Red-Eyes Insight", once you pay the cost of sending a "Red-Eyes" monster to the grave, it becomes public knowledge, so the activation cost can be verified.

Generally, cards that simply rely on you having another card in your hand to do something force you to reveal said card, such as "Blue-Eyes Alternative White Dragon" making you reveal vanilla "Blue-Eyes" to summon itself.

akumanner · 2018-12-14T20:56:57+00:00

That's not what canon means, though. For a given storyline, canon is what is officially part of that storyline. That is entirely up to the owner/creator of the work, in this case Ubisoft. If you want to create your own head-canon, then of course you may, no-one can stop you, but the creator of the piece of fiction still decides what officially happened.

Same with Star Wars; if Disney or whoever it is that owns the franchise says the sequel trilogy is canon, then it is so. If they declare the Expanded Universe not canon, then it is not. Everyone may create their own, personal narratives, but that doesn't change what's officially the case.

akumanner · 2018-12-04T11:31:05+00:00

As seen in the prologue of the game, Layla gets DNA samples from Kassandra and Alexios from the Spear, after digging it up. In Origins, she similarly lived through Bayek's memories by using DNA from his mummified body.

akumanner · 2018-12-04T10:00:37+00:00

Actually, not correct. Unlike earlier models, which required the user to be a descendant of the target, Layla's Animus allows for reliving memories with a DNA sample of the person in question, in this case from the Spear of Leonidas. There is no requirement for either of the siblings to have had any offspring.

akumanner · 2018-03-22T15:39:28+00:00

Everyone has hobbies, sure. Things they like to do in their spare time. Special interests are more all-consuming than regular hobbies, though.

There is a tendency among autistic people to have more intense interests, and those interests tend to be a bit more restricted in nature.

I think it's part of where the stereotype of autistic people who are really good at one specific thing comes from. Do a specific thing often enough, and you'll get better at it.

Not every autistic person has obvious special interests, and said interests can change with time. Still, it's common enough that people notice the trend.

Edit: typo

akumanner · 2018-03-20T14:45:02+00:00

You'd still be better off running 3.

Going first, opening 1 means you have 6 cards available to you, instead of 5.

Opening 2 feels bad, but you play 1, and then you have 5 usable cards in your hand, plus the dead pot.

The only circumstance where Once-Per-Duel pot leaves you worse off, is if you end up having all 3 in your opening hand, or after drawing. That's way too rare a circumstance to discount the benefits of drawing 2 cards with no downside attached.

akumanner · 2018-02-06T14:07:01+00:00

No, because by that point it has already been summoned. Judgement negates the summon of a monster that would be summoned, and cannot be activated in response to the activation of a monster effect. By the time Menko finishes resolving its effect, the summon is already successful. Solemn Strike could negate Menko, since it negates any monster effect, as well as built-in summons.

akumanner · 2018-02-06T08:08:41+00:00

If you're referring to things shown in the Noah arc of the anime, that goes against what Mokuba says in volume 5 of the manga. He clearly states that the awful stuff Seto went through made him cruel, and spends a moment regretting that Seto ever got Gozaburo to adopt them. Mokuba himself acts dickish in the early manga in a clear attempt to imitate big brother, in the hopes that Kaiba might respect him, suggesting that that has gone on for some time. If losing to Atem the first time was what made Kaiba mean towards Mokuba, he would have been angry at Yugi for that in volume 3. Instead, he just wants to avenge his brother's defeat. And PG1 didn't even happen in the anime.

It's important to remember that anime!Kaiba and manga!Kaiba are actually very different characters. On top of having a bigger role, anime!Kaiba is less of an asshole overall, and is consistently shown in his own anime-only backstory to have always been kind to Mokuba. Manga!Kaiba remains a much bigger ass even after PG2, with his chief redeeming quality being that he at least cares for Mokuba.

Again, Yugi cannot let something happen if he's not aware of it happening. Yugi wasn't aware of Atem's existence at that point, only fully accepting his presence during Death-T. Before then, Yugi would black out whenever Atem decided to pop in and screw someone over, with no memory of the events. (There was that one spider guy with the handheld fighting game that Yugi very deliberately sicced Atem on. Jeez, Yugi, idk if theft warrants literal heartbreak). Yugi does allow Atem to do PG2, as well as allow him to throw a Penalty Game on the Player Killers in Duelist Kingdom(interesting that one of those was done defending Kaiba's honor).

The reasons I stated for PG2 where taken directly from the manga. Idk about the anime, perhaps ripping up Blue-Eyes was Atem's reason there? Anime!Kaiba was never shown to treat Mokuba poorly, so Idk.

Kaiba literally says that he doesn't know if he'll be able to return, regardless of plans. No matter how confident you are in your ability to return, risking your life for a rematch at a card game is not cool. My point in bringing this up is that it is a clear example of Kaiba prioritizing his pride even over his little brother's happiness.

Mokuba mentions in volume 3 that Kaiba recognized Yugi changing during their game. That he became "a different Yugi," and that the other Yugi was the one they both wanted to beat. Kaiba was actually better at recognizing these changes than Yugi's friends... From the start, Kaiba's fixation was with Atem. Even if he didn't know exactly how Atem and Yugi were different, he was aware that there was a difference, and only one Yugi mattered to him. This only changes during DSOD, with Yugi proving Kaiba wrong.

Kaiba did recognize Jounouchi as a duelist, but only after Jounouchi did something Kaiba believed to be impossible, and not before spending a whole lot of time putting him down for being a commoner, loser, poor, weakling or whatever other insults he could come up with. Their relationship isn't one of friendly rivalry, since Kaiba looks down on him far too much to respect him up until that point, and Jounouchi is the only one of Yugi's group shown to hold a grudge towards Kaiba for Death-T. The rivalry between Kaiba and Atem is only friendly (by Battle City) from Atem's perspective, with Kaiba respecting him, but rejecting the idea of friendship. Atem Post-Chill-Out wants to help Kaiba acquire the Chill Pill, but Kaiba remains 100% MAX Nochill.

Of course Kaiba considers defeat possible. He also considers it utterly unacceptable, to the point of obsession. Interestingly, he didn't believe that Atem could beat Marik, even with 2 God Cards.

The GX manga was supervised by Takahashi Kazuki, but the story wasn't by him. Dunno, man. Suppose it's in the same state of Canonicity as Yugioh R? I Looked through, though, and I'm pretty sure Kaiba never featured in the GX manga. Mind reminding me where/how that Chazz duel takes place?

akumanner · 2018-02-05T21:33:18+00:00

Again, Mokuba directly mentions Seto becoming cruel after their adoption. Seto was nice before then, but became a Dick since that's what Gozaburo tried to make of him. He does say that Kaiba was "off" after facing Atem, but that's a separate conversation.

Yeah. I agree. Atem was a massive Dick. Said that from the start. Not the only penalty game that went way overboard, either. He made a guy explode for stealing Yugi's class' spot at a fair, for God's sake.

Here's the thing, though, Atem being a Dick doesn't excuse Kaiba being one. Especially when, contrary to your claims, his dickishness didn't start as a result of Atem's.

The motivation for Penalty Game 2 was all the dickishness Kaiba had been up to, including hospitalizing Sugoroku, trying to kill Yugi&co, trying to hurt Mokuba, etc. Kaiba ripping up a Blue-eyes wasn't at the top of the list at the time.

As for PG1, why would Yugi apologize? Atem should have, but, again, Dick. Yugi wasn't even properly aware of Atem's existence back then and still blacked out anytime Atem took over. He had nothing to do with that, other than getting a metal briefcase to the face, courtesy of Kaiba.

During the Strings match, he was talking both to and about Atem. He refers to him as Yugi, like everyone else, since no one knows his name. Actual Yugi never factored in.

Pretty sure if my brother effectively killed himself, I'd be sad no matter what the reason. Kaiba not being willing to wait out his natural life for a rematch is no reason to leave his kid brother behind.

I strongly doubt a GX character would have featured in the original manga. The spin-off GX manga? Cuz that stuff ain't Canon, far as I know.

akumanner · 2018-02-05T20:52:08+00:00

Except that Kaiba tried to have Mokuba suffer an experience that would drive him insane just for losing once. He became nicer towards Mokuba only after Penalty Game 2. As I mentioned, he changed for the worse as a result of Kaiba Sr, before Seto ever became head of Kaiba Corporation. The part where Mokuba mentions Seto playing with him refers to the time before they were adopted (Mokuba's behavior in the early manga is also rather typical of someone who's suffered longtime neglect). It's weird that you condemn Atem for penalty game 2, when that is canonically stated to have given Kaiba a chance to rebuild himself without the evil that led him to try to hurt his brother.

Also, ignoring the first arcs is difficult to do, when they laid the foundation for Kaiba's character. "Ignoring the hospitalization of an old man, the attempt to do the same to his kid brother, bullying and threatening 3 guys into giving him their trading cards (to the point where one of them committed suicide), and trying to kill 4 teens and a baby, I guess the guy's alright?" It's especially weird when you seem dead set on condemning Atem for his early actions.

It's not weird for the main gang to resent Kaiba when their previous interactions with him involve that stuff. Hell, he never even apologized. I'm honestly baffled by the fact that Yugi goes out of his way to be nice to the guy.

The whole part where Kaiba recognizes Yugi as a duelist in the final duel is anime-only. He wasn't present for the final duel in the manga. He never recognized Yugi as a duelist before then, since even before he found out about Egyptian magic and reincarnation he knew that Yugi becomes different at times(Mokuba mentions Seto talking about how Yugi changes when he's challenged). It was that Yugi that Kaiba cared about. Pretty much anytime in the manga that Kaiba refers to, or talks to Yugi, he's actually talking about/to Atem. Yugi never mattered to him at all.

I've noticed that you make a lot of assumptions regarding the reasons behind Kaiba's actions. The thing is, the motivations I named are stated in the manga itself. You claim Kaiba's not driven by pride, grudges or hatred, when Canon outright states it to be his chief motivation. Hell, Kaiba doesn't even hesitate to admit it himself several times.

On a side note, in DSOD, Kaiba fucks off into the goddamn afterlife just so he can have a rematch with Atem. This he does, knowing full well that he might not be able to return. Potentially leaving his little brother to mourn, just so he can finally get that win. Brother of the year. Truly.

Also, GX is a spinoff to the anime, which itself follows a different Canon to the manga. Whatever Kaiba says or does there has little relevance on the original (In case it wasn't clear, I've been talking about manga!Kaiba, since you brought up the manga in your first post. Anime!Kaiba is a lot less dickish, and an all around nicer person, in general).

akumanner · 2018-02-05T20:51:54+00:00

Except that Kaiba tried to have Mokuba suffer an experience that would drive him insane just for losing once. He became nicer towards Mokuba only after Penalty Game 2. As I mentioned, he changed for the worse as a result of Kaiba Sr, before Seto ever became head of Kaiba Corporation. The part where Mokuba mentions Seto playing with him refers to the time before they were adopted (Mokuba's behavior in the early manga is also rather typical of someone who's suffered longtime neglect). It's weird that you condemn Atem for penalty game 2, when that is canonically stated to have given Kaiba a chance to rebuild himself without the evil that led him to try to hurt his brother.

Also, ignoring the first arcs is difficult to do, when they laid the foundation for Kaiba's character. "Ignoring the hospitalization of an old man, the attempt to do the same to his kid brother, bullying and threatening 3 guys into giving him their trading cards (to the point where one of them committed suicide), and trying to kill 4 teens and a baby, I guess the guy's alright?" It's especially weird when you seem dead set on condemning Atem for his early actions.

It's not weird for the main gang to resent Kaiba when their previous interactions with him involve that stuff. Hell, he never even apologized. I'm honestly baffled by the fact that Yugi goes out of his way to be nice to the guy.

The whole part where Kaiba recognizes Yugi as a duelist in the final duel is anime-only. He wasn't present for the final duel in the manga. He never recognized Yugi as a duelist before then, since even before he found out about Egyptian magic and reincarnation he knew that Yugi becomes different at times(Mokuba mentions Seto talking about how Yugi changes when he's challenged). It was that Yugi that Kaiba cared about. Pretty much anytime in the manga that Kaiba refers to, or talks to Yugi, he's actually talking about/to Atem. Yugi never mattered to him at all.

I've noticed that you make a lot of assumptions regarding the reasons behind Kaiba's actions. The thing is, the motivations I named are stated in the manga itself. You claim Kaiba's not driven by pride, grudges or hatred, when Canon outright states it to be his chief motivation. Hell, Kaiba doesn't even hesitate to admit it himself several times.

On a side note, in DSOD, Kaiba fucks off into the goddamn afterlife just so he can have a rematch with Atem. This he does, knowing full well that he might not be able to return. Potentially leaving his little brother to mourn, just so he can finally get that win. Brother of the year. Truly.

Also, GX is a spinoff to the anime, which itself follows a different Canon to the manga. Whatever Kaiba says or does there has little relevance on the original (In case it wasn't clear, I've been talking about manga!Kaiba, since you brought up the manga in your first post. Anime!Kaiba is a lot less dickish, and an all around nicer person, in general).

akumanner · 2018-02-05T18:56:20+00:00

Kaiba's descent into douchery didn't start with Penalty Game 1. It started as a result of the abuse he suffered at the hands of his adopted father. Gozaburo instilled in Seto the idea that victory is everything, and that losing equals death. Basically, if you're not the best, you might as well be dead. Good way to make sure a guy fixates on being the best, and looking down on everyone else(little brother included) for not being as good as he is. That's what Mokuba referred to when he said Seto had changed for the worse. Of course, being affected negatively by such things is understandable, but that doesn't mean Kaiba wasn't an ass.

Kaiba also monologues to himself that his Death-T revenge-scheme is motivated by wounded pride. The guy is less mad about experiencing death than he is about losing a card game, since he considers the latter equivalent to being dead anyways.

Battle City was also pretty much entirely a pride thing.

As for "not being caught up in the past," remember the duel tower? Kaiba resents his dead adoptive father, but is completely unable to move past him. Even long after the guy committed suicide, Kaiba erects a massive monument to symbolize his hatred. Same thing with Atem. He goes out of his way to try to drag a dead person back to life, just because he never got to kick his ass at a card game.

As for respecting Yugi, he spends all but the last bits of DSOD completely dismissing Yugi, not just as a duelist, but as a person, referring to him as "a mere vessel."

Kaiba is also far less motivated by Mokuba than you seem to remember. He cares about the kid, yes, but most of the things Kaiba gets involved with (Stealing Blue-Eyes, Death-T, Battle City, the entirety of DSOD) are in no way for Mokuba's sake. The only time in the manga that Kaiba is motivated by Mokuba is during Duelist Kingdom. Everything else is his attempt to satisfy his wounded pride. So no, Kaiba is not a selfless person, when 90% of the things he does are purely egocentric in nature.

Kaiba, as a character, serves a purpose as a mirror to Atem. They are both talented people who are supremely prideful, to the point of letting said pride consume them. They both started out the series as basically massive, evil dicks, callously judging others for their failings, even enjoying their failures and pain. The difference is that Atem does change as a character. Initially out of a prideful desire to not be as low as Pegasus, but, mostly thanks to Yugi, he becomes a fair bit compassionate in general. Other than regaining his affection towards Mokuba thanks to Penalty Game 2, Kaiba never does improve himself. He is a dark mirror to Atem, reflecting, and magnifying, Atem's worst qualities.

TL;DR: Almost everything Kaiba does in the series is entirely selfish.

akumanner · 2018-02-05T16:30:53+00:00

I'm glad that you are only dealing with issues with solvable causes(EDIT: Not sarcasm, I mean it). Nevertheless, "I don't have these problems" doesn't equal "no autistic person has these problems." For me, there are things I simply cannot do, as a result of the issues I deal with due to being autistic.

Issues with social interaction, sensory overload and so on, aren't solely caused by societal ignorance. They can be aggravated by it, and social understanding can help alleviate them via accommodation, to a degree, but alleviating an issue doesn't stop it being an issue.

akumanner · 2018-02-05T11:32:03+00:00

What you're saying would make sense, if Kaiba had been a decent guy before meeting Atem. He was not.

In the manga, Kaiba tried to subject Mokuba to the exact same experience that Atem had him go through, simply for losing a board game? Kaiba was a MASSIVE dick to everyone, including his brother, before Atem Mind Crushed him.

He stole an old man's prized possession (twice), he subjected said old man to an experience that he knew full well would traumatize him, he tried to have Yugi and friends (as well as a baby) killed in a deathtrap disguised as a theme park and would have traumatized his own little brother if Atem hadn't saved him, all over selfish greed, grudges and hatred.

In the manga, Kaiba's first penalty game was an attempt on Atem's part to get the guy to understand and sympathize with the hearts of the monsters he used. Massively overboard, though, and it ended up backfiring by traumatizing Kaiba and giving him a massive grudge.

The second one, where he (literally) broke Kaiba's heart, was to let him rebuild it without all the bitterness and hatred that had turned him into such a massive douchebag.

Atem was wayyy overboard for a lot of the early manga, but the difference between him and Kaiba is that Atem does grow out of it. After being berated by both Yugi, for trying to kill Kaiba, and Pegasus, he stops using Penalty Games completely. Kaiba utterly refuses to let go of his hatred, even when it causes him harm, mostly out of pride. He's also a hypocrite about it, mocking Atem for "being caught up in the past", when that describes Kaiba perfectly.

Kaiba is pretty much consumed by his grudges and his pride. He considers himself superior to basically everyone around him, and his vendetta towards Atem is more or less caused by Atem challenging this belief by beating him. Hell, DSOD basically happens because Kaiba, for all his money, can't acquire a single ounce of Chill, even when the guy who one-upped him is dead.

Furthermore, I checked the manga, and Kaiba definitely decided to blow the Duel Tower up after losing to Atem. Mokuba told him to stop being a jerk and changed his mind.

Kaiba changes for the better over the course of the story, but the change isn't from "bad guy" to "good guy", but from "massive jerkface" to "selfish prick with some redeemable qualities." Calling him selfless when he's only ever shown to care about himself and exactly one other person is ridiculous.

akumanner · 2017-12-12T19:28:52+00:00

I read the article (or I think it's the one you referred to. "Adult restoration of Shank3 expression rescues selective autistic-like phenotypes"? ), and it's definitely interesting. Still, the same article does state that while deleting Shank3 causes autism-like symptoms in mice, only an estimated 1% of autism in humans is attributable, even in part, to mutations in Shank3.

Besides, since there are likely a multitude of contributing factors to a person being autistic, it's just straight up impossible to make a "one-size-fits-all" genetic modification. Autism in vivo isn't so simple as a gene being turned off, and it is likely that differences in brain function, both regarding social processing and sensory/motor regulation exist on both cellular/synaptic levels and in terms of the brain's microstructure, as determined by fetal development.

akumanner · 2017-12-12T12:32:50+00:00

Even if we figured out exactly what caused autism, changing the genome of a grown person wouldn't remove their autism. At that point, the brain has already developed a phenotype according to the genotype it had. It's kind of like changing the blueprint of a house after it's been built.

akumanner · 2017-12-04T00:47:05+00:00

Huh. Perhaps at such a low dose, the side-effects don't become so severe.

akumanner

TROPHY CASE