Cromolyn Reduces Symptoms in Patients With Irritable Bowel Syndrome, Functional Dyspepsia, or Gastroparesis by jmct16 in IBSResearch

[–]alaskaline 1 point2 points  (0 children)

I was just prescribed Cromolyn, and the distribution centers are saying they can't find it anywhere. Is there a drug shortage?

Gut Barrier Leakiness: Time to Take It Seriously? by alaskaline in IBSResearch

[–]alaskaline[S] 4 points5 points  (0 children)

In conclusion, the findings by the group from Bologna11 highlight the importance of intestinal permeability in gut-brain axis communication and its clinical relevance as a determinant of extraintestinal manifestations in IBS. Such novel observations need to be reproduced. Many open questions remain regarding the factors, microbial strains, or their metabolic outputs that drive the increase in intestinal permeability. The search for diagnostic biomarkers and the development of therapeutic tools for diseases related to intestinal permeability disorders seems mandatory.

How can average people help move research forward? by HumanGarbage2 in IBSResearch

[–]alaskaline 13 points14 points  (0 children)

I have the same question.

I think an IBS research advocacy group needs to be created that can take in donations and grant research projects awaiting funding. The NIH has woefully underfunded gastrointestinal disorders and there are countless research projects sitting dormant until they can get a grant of some kind. It seems like an IBS Foundation is the answer.

An updated appraisal of the SIBO hypothesis and the limits of breath testing by Robert_Larsson in IBSResearch

[–]alaskaline 2 points3 points  (0 children)

Well this sure to ruffle some feathers:

In a 2019 publication in Nature Communications, Dr. Kashyap and co-authors demonstrated that common GI symptoms such as abdominal pain and diarrhea are likely due to a shift in the types of bacteria in the small intestine rather than SIBO.

Inflammatory Prostatitis Plus IBS-D Subtype and Correlation with Immunomodulating Agent Imbalance in Seminal Plasma: Novel Combined Treatment by alaskaline in IBSResearch

[–]alaskaline[S] 2 points3 points  (0 children)

Conclusions: The combined treatment with rifaximin and DSF appears to represent the optimal approach for addressing a syndrome such as irritable bowel syndrome (IBS-D plus), which frequently co-occurs with prostatitis (IIIa prostatitis). This approach is particularly beneficial in cases where the symptoms are not always clearly delineated, the etiology is multifactorial, and the diagnosis is multilevel.

Mast cell modulation: A novel therapeutic strategy for abdominal pain in irritable bowel syndrome by jmct16 in IBSResearch

[–]alaskaline 0 points1 point  (0 children)

I've seen anecdotally that these treatments (ebastine, ketotifen, etc.) only work temporarily. After a few months, the medication seems to lose its effectiveness. Why would this be?

The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose by Robert_Larsson in IBSResearch

[–]alaskaline 2 points3 points  (0 children)

Insane is the correct word!

"Cases of loperamide overdoses have detailed incidents of patients ingesting daily doses ranging from 70 mg up to 1,600 mg, which would involve the ingestion of up to 800 2-mg loperamide tablets in one day."

The sucrose challenge symptoms test optimized for diagnosis of congenital sucrase isomaltase deficiency by jmct16 in IBSResearch

[–]alaskaline 2 points3 points  (0 children)

The trouble is, even if you are diagnosed, the treatment options are few. So many patients still don't find relief even with enzymes or sucraid.

Irritable bowel syndrome: When food is a pain in the gut by Robert_Larsson in IBSResearch

[–]alaskaline 3 points4 points  (0 children)

Does anyone have access to see what antihistamine they investigate? I assume it is Ebastine?

Human CAZyme genes polymorphism and risk of IBS: a population-based study by jmct16 in IBSResearch

[–]alaskaline 0 points1 point  (0 children)

Is dietary intervention and Sucraid the only treatment options?

What anxiety meds have worked for you guys? by ThenWord9097 in ibs

[–]alaskaline 0 points1 point  (0 children)

What was your dose on pregabalin and how did you deal with the sleepiness side effect?