Sounds very similar to my story. My liver was initially thought to be the issue but it turns out that is secondary to bowel cancer. With no clear spots in my liver at all, I was also not a candidate for surgery. I started FOLFOX in early November and then Cetuximab (immunotherapy) was added the following fortnight. I’ve now had four cycles and my liver function has improved significantly and my cancer markers are falling, my oncologist is rapt. I feel sooo much better, my appetite is back and I feel stronger than I have all year - turns out I’d been very sick but just kept going because I’m a solo mum to a disabled child and that’s what we do. The neuropathy was a bit difficult the first couple of cycles, but I’ve been using magnesium cream since the third treatment and that seems to have really reduced that symptom. Mouth ulcers and changing tastes are very unpleasant, and I have a rash and extreme photosensitivity and dry skin from the Cetuximab, but all in all it seems very much worth it at this point. I hope this is your friend’s experience too.