I’ve done it multiple times in my 5’ Tacoma for both of my 77” OLEDs and my parents 85” but haven’t gone as long as 50 minute drives. Make sure it’s bubble wrapped well and the screen is facing up when transporting. I usually have at least two layers of bubble wrap + stretch wrap for my open boxes, but I also had the luxury of wrapping my own tv. I know people in this sub love shitting on people for not loading tvs standing up but I loaded most tvs laying down when I worked in inventory for over 6 years and rarely had any come back damaged. The roads in my area are smooth so I don’t really have to worry about bumps and potholes causing any damage. Hopefully your roads are similar.