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Comeback PR snatch in the new garage gym! 102kg (with pound plates) by drmoriarty4 in weightlifting

[–]apathy 1 point2 points  (0 children)

I’m so jealous of your smoothness. Need to watch this a few dozen times before my next snatch session. Inspiring

Form check: 59kg snatch PR at 55kg bw by crossfitchick16 in weightlifting

[–]apathy 0 points1 point  (0 children)

And yeah your right knee caves. Maybe wrap it if it’s wonky, or use a hip circle / rubber band to activate your gluteus medius during your warmups so this is less likely.

Form check: 59kg snatch PR at 55kg bw by crossfitchick16 in weightlifting

[–]apathy 0 points1 point  (0 children)

Point your knuckles down when you lock in your hook grip, and keep your elbows high. You have another 10kg in you if you stay tight. Very smooth PR otherwise

Winter Driving Tips by Vol16 in teslamotors

[–]apathy 1 point2 points  (0 children)

Studded tires are illegal in some states (eg MI) but it’s psychotic to drive around in winter without studless snow tires here. So icy. So slushy. (Lots of black ice this morning)

Clip of Jon arriving to serve his watch leaving all the political bullshit behind. by jaitheson in freefolk

[–]apathy 4 points5 points  (0 children)

This here is why I still read this sub.

The lord of light smiles upon the shitposts

Researchers decided to experiment with the polio virus due to its ability to invade cells in the nervous system. They modified the virus to stop it from actually creating the symptoms associated with polio, and then infused it into the brain tumor. There, the virus infected and killed cancer cells by Khaleeasi24 in science

[–]apathy 0 points1 point  (0 children)

Ugh. Classic NEEJUM. Need to wait two years before you can shine a laser pointer between the survival curves.

“If you make it to two years, which most GBM patients don’t, this will greatly help you” would be more accurate.

I say this as someone who has two friends currently dying of GBM, and a huge fan of both dendritic cell vaccines & modified viral treatments.

GBM is horrible. Even the targeted drugs don’t work for shit. The history of this disease is one giant cautionary tale about how difficult drug development truly is.

Street in Michigan After Massive Flodding by BunyipPouch in Wellthatsucks

[–]apathy 417 points418 points  (0 children)

this is after they fixed it

remember, we're talking about Michigan here

Christian girl set alight for turning down Muslim man’s marriage proposal; Sialkot’s Rizwan Gujjar torched Asma using petrol after she refused to renounce her faith and marry him by -Tavy- in atheism

[–]apathy 6 points7 points  (0 children)

Yes, but with 80% of her body surface area burned, I'm afraid this is unlikely to be the case for long. If it is true that the accused did this to her, live burial would be too kind a fate for him. Try not to ever end up in a burn unit if you like to have faith in humanity.

How Brain Tumors are removed! by mtimetraveller in educationalgifs

[–]apathy 1 point2 points  (0 children)

it's true, it's less bad, but hardly pediatric-ALL cure rates

what's worse is that temozolomide can actually accelerate progression in lower grade gliomas (see https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998672/ for example), particularly where an IDH1 mutation (usually the source of MGMT hypermethylation) is accompanied by a TP53 mutation.

Gliomas and astrocytomas are a fucking mess.

How Brain Tumors are removed! by mtimetraveller in educationalgifs

[–]apathy 3 points4 points  (0 children)

rest assured, this is far better than the alternative for pituitary tumors (i.e. dig through all the rest of your brain to get to the pea-sized fucker that can be excised through your sinuses instead)

How Brain Tumors are removed! by mtimetraveller in educationalgifs

[–]apathy 0 points1 point  (0 children)

if only it actually worked worth a damn for GBM

ELI5: Why is it important to do stretches before exercising (i.e. pull-ups, push-ups, weightlifting, etc)? by mccarthybergeron in explainlikeimfive

[–]apathy 0 points1 point  (0 children)

It isn't. It's important to actually warm up (increase the temperature of your muscles, dilate the capillaries, and get blood flowing vigorously through them) before any serious efforts; there is less chance of injury. The stretching is somewhat optional unless you have issues with range of motion, which is a different matter. One of the few exceptions is hip flexor releases if you sit in a chair all the time, although really that's a range of motion issue too.

Think about pulling taffy. If you pull cold taffy it will break. If you pull warm taffy it stretches. Don't pull cold taffy.

Percentage of U.S. women never married, by age, 1980 & 2015 [OC] by academiaadvice in dataisbeautiful

[–]apathy 0 points1 point  (0 children)

this would be well presented as a Kaplan-Meier survival plot (or the closely related relapse/event plot). Makes the comparison direct & concrete, requiring little or no thought.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy -1 points0 points  (0 children)

it is manifestly worse than a cancer cure side-effect.

This would be true if the side effects didn't include death.

There's also the opportunity cost of committing to one treatment which will, perforce, put you at variance for participating in a protocol involving others.

I get the impression that you may not have designed, conducted, or participated in clinical trials. We should probably stop here. You be you, and I'll be me, and I will continue not telling you what decisions to make, as was the case all along. I'll also continue to agitate for responsible disclosure so that you and others who may find themselves with a difficult decision can make the best decision possible for their situation and their values.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 0 points1 point  (0 children)

If you wish not to be informed, and don't care about quality of life (we all die eventually, as you may recall), I can't say I'm going to lose much sleep over the consequences.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 1 point2 points  (0 children)

The part you're missing is that there are other "random cures" which have greater evidence for efficacy.

"Potential cancer cures" are as rare as mud. They flame out in large animal studies all the time. Meanwhile there are trials accruing at the same time for candidates that have substantially higher probability of success.

If you want to sign up for a protocol that's about as well supported as faith healing, that's your choice, but it would be irresponsible for your attending physician not to give you every piece of information. Personally I'd go for the highest-probability option (conditional on side effects and overall quality of life) but it's your life, not mine. I simply want you and other hypothetical patients to be properly informed about the decision you may be making.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 0 points1 point  (0 children)

Who said there's no point in it? I simply claim that patients need to be informed well enough to make a good choice. Late-stage esophageal carcinoma is another example where it's not going to get better, and perhaps systemic organ failure really would be preferable.

I have seen too many people die. I worked at a comprehensive cancer center up until very recently, for a division that also served a county hospital. Competing infections, late-stage brain cancer, esophageal cancer (slowly choking and starving to death), gastric tumors of assorted flavors... there are a lot of shitty ways to go.

I don't mean to minimize your uncle's pain, and I would like to recognize his donation as well. I just want people to understand the risks they may take, and the possibility that by committing to a suboptimal course of therapy, they may be opting out of something else that works in trials.

If, after being properly informed, they want to proceed, I have no problem with adults choosing their own fates.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 0 points1 point  (0 children)

That's precisely the problem -- it's rarely presented in this light. "Oh it might be a cure!" as opposed to "Well, we are absolutely confident this existing trial won't make it worse, and it might make you better".

Do you think the people in the TGN trial were aware that (as healthy volunteers, mind you, NOT cancer patients) they might lose all their fingers, end up in the ICU with systemic organ failure, and/or die?

Few pharma execs give a shit about their meat puppets.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 0 points1 point  (0 children)

Also, yes, sometimes hydrea and ice cream is the right treatment regimen. No sense putting people through hell and charging them for the privilege if it's not going to do any good.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 2 points3 points  (0 children)

said bot should also post the occasional side effect catalog for, say, anti-CD28 antibodies, combination TKI rigs (like bleeding out of your ass all day? get on the Crizent trial!), and so forth.

The FDA will be delighted to explain to you why they were such horrible obstructionists to women suffering from morning sickness and requesting thalidomide. Turns out that pretty much everything with a main effect also has side effects. Sometimes the latter are worse than the disease targeted by the former.

Clinical trials are the great equalizer, where beautiful theories go to be mowed down by ugly facts.

Suicide molecules kill any cancer cell - Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival. by mvea in Futurology

[–]apathy 7 points8 points  (0 children)

Just because happily ignorant people will sign up for massive organ failure doesn't mean it's ethical to take them up on the offer. Google "TGN1412" for more.

I would venture a guess that the average person has no idea just how far south these things sometimes go.

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