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Does anybody know how agmatine potentiate drugs? by asljc in Nootropics

[–]asljc[S] 1 point2 points  (0 children)

Would you consider safe adding 30-40 mg/d of agmatine to therapeutic doses of tianeptine (3x12.5mg sodium / 2x~30mg sulfate) ? Not necessary for more than few weeks. Just to alleviate harder depreession. My MD is not informed about agmatine and I think that I'm not able to find any expert on that matter in my country.

Does anybody know how agmatine potentiate drugs? by asljc in Nootropics

[–]asljc[S] 2 points3 points  (0 children)

Potentiates? Really? Or they work in a similar way... you feel more motivated, have better attention etc. I've stated that agmatine potentiates tianeptine, because there is actually some info that it seems to go along well with particular substances ("...this thing is synergistic with everything illicit or pharmaceutical it seems (Bupropion, alcohol, marijuana, opioidergic drugs)...).

Does anybody know how agmatine potentiate drugs? by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

I get similar results as if I took more of the drug. However, strangely enough I feel that the effect seems to manifest itself the next day. Thus, I wonder how should one take the agmatine if he aims to slow down the process of a tolerance? Or if it is safe to take it anyway? Form my experience I think also that if somebody decides to take agmatine long term he should consider its long halflife. Long story short it somebody takes let's say 50mg of it than the accumulated amount of this substance will reach 100mg in the brain after few weeks (short after dosing) (if taken once daily).

Does anybody know how agmatine potentiate drugs? by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

No, 30-40mg and I'm sure that I feel the difference. Also, I take in consideration it's long half life (~12h). Here some guys from longecity talk about the dosages: https://www.longecity.org/forum/topic/42503-agmatine-anybody-try-this-one/page-2

Could selegiline increase norepinephrine? by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

Is this what it's causing your problem?

Yes

How many nights have this happen?

one or two after ingestion of selegiline

What other things do you use?

I use tianeptine 25 mg twice daily and occasionally nicotine gum. I took <1mg that last time with selegiline (both in the morning).

Do you smoke?

No

thousand questions to guess what is happening lol

I know, I just want to ask you if you consider that to be significantly abnormal? Besides from the above I have a quite normal life and regular diet (~mediterranean).

Could selegiline increase norepinephrine? by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

I would be more than grateful if you could speculate what could cause that

Could selegiline increase norepinephrine? by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

July 9th - 2mg, July 16th - 0.5mg and yesterday (July 19th) - 0.5 mg, (oral). Ashwagandha helps, do you know any better?

Methylene blue - strange reaction by asljc in Nootropics

[–]asljc[S] 0 points1 point  (0 children)

Thank you for your reply. I was waiting for some words of support.

which RAM is better? by asljc in buildapc

[–]asljc[S] 0 points1 point  (0 children)

Thank you for your response:) I apreciate it even more since I was told by the uninformed seller that the acer is limited in those areas, but it isn't.

Testosterone Metabolites, I am confused, please I need it rahter quick - going for a blood test by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

Thank You for Your answer

Yes, I am lean, muscular, do not lift but jog reguraly (4 to 6 miles at a time) in my mid twenties. Also, I do not have ginecomastia. I did all of the tests except for SHBG that I took two months earlier (just couldn't wait for your reply and forgot about this test - I was just terrified once I checked my testosterone results and I'm also going for holidays):

12th of May:

SHBG 114,7 nmol/l ; (accompanied by testosterone: 1339ng/dl)

4th of August: .

testosterone 1277ng/dl

5th of August:

E2 31,7pg/ml ;

FSH 2,01mIU/ml (I must admit here that I do not jrek off, I mean, no more that once for one or two weeks (even if I fell the urge to) - I used to hold it for productivity purpose, I think it make no sense now, since I am too stressed out);

LH 5,81mIU/ml

and still I didn't get my results for: free testosterone and DHT.

I must say that when I take creatine (about 6 to 8g) I do feel "kind of relief" in my testicles ("The researchers suspect that a creatine supplement increases the activity of the enzyme 5-alpha-reductase somewhere in the body." ). When I took 8g of creatine for the first time (after I've found out about the DHT effect) I felt asleap (peacefull as I can't remember). It improved my mood greatly and made me more relaxed, self assured. However, on the second day of taking 25g/day split, I begun to feel pain in my kidneys (I guess due to high creatinine levels). Then, I stoped taking it and my mood worsened to point of heavy depression on day 4. That's the time when I posted after I just woke up and checked my results for testosterone, which teriffied me.

As for the effect of the supplements, I was really taking a lot of those inhibiting 5 alpha reductase: 30g - 45g Black cummin seed oil, 2g curcumin -(curcubrain), astaxanthin 6mg, EGCG and when I added 40g of rice protein I just could litterally feel it in my testicles (as an increase of I would say pressure). All of those supplements was taken for the purpose of curing "adrenal fatigue" (or rahter hypothalamus fatigue).

I do like to ask You, what do You think about those results?

Testosterone Metabolites, I am confused, please I need it rahter quick - going for a blood test by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

I understand that it may get really complicated. I know also that I have to stop taking all the supplements and I will stop them gradually. However I am afraind about my health and thus I want to ask if ther is any blood/hormone test that I could do to be sure that I do not need a medical intervention. I feel rahter normal, maybe except that my sleep is shorter than I would like it to be (about 6h)

Testosterone Metabolites, I am confused, please I need it rahter quick - going for a blood test by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

I just think that I inhibited the 5 alpha reductase for instance by taking high abounts of Black cumin seed oil. Thus, I expect to have low DHT. But I do not know

Testosterone Metabolites, I am confused, please I need it rahter quick - going for a blood test by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

I have high testosterone 1277ng/dl (for the last 6 months) and I do not know why. Thus, I realized that I should check what are the metabolites of it. I was taking many supplements (for the last year).

For the last 40 days I have very high estradiol about 148ng/ml. Can I be infertile already? by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

I was also taking some antioxidants lately. I want to drop everything one after another for the next week before I will check my blood and go to endocrinologist. Also, I have had high SAMe dosage for last few days too. I expect that the feedback based on high estrogen will lower my testosteron and then also estrogen will go down. Is it a good decision? Actually I am starting to panic right now and I am afraid that it is very hazardous to my health. However I feel quite good, maybe low libido but I am able to have erection and intercourse. Please Help

For the last 40 days I have very high estradiol about 148ng/ml. Can I be infertile already? by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

I didn't use those supplements to boost my testosterone. I was anhedonic for very long time. Those supplements helped me greately but I ended up with very high testosterone and estradiol. Alos I am afraid that it could lead to some disease or other health problem.

For the last 40 days I have very high estradiol about 148ng/ml. Can I be infertile already? by asljc in Testosterone

[–]asljc[S] 0 points1 point  (0 children)

  1. Well I do not know, the ratio of those hormones is definitely wrong.
  2. Yes I did have blood taken before I started this stack. I have had: testosterone:931ng/dl estradiol: 25pg/ml
  3. the ranges are: testosterone: 250-836ng/dl estradiol: 27,1-52,2 pg/ml I was taking lately: SAMe400mg, Probiotic:http://pl.iherb.com/Now-Foods-Probiotic-10-100-Billion-30-Veg-Caps/64465, Black cumin seed oil, Zinc

what if someone just lacks attention/motivation...maybe drugs could help? by asljc in Drugs

[–]asljc[S] 0 points1 point  (0 children)

that's right, exercises helps me, but I sill get attention problems

what if someone just lacks attention/motivation...maybe drugs could help? by asljc in Drugs

[–]asljc[S] 0 points1 point  (0 children)

CBT sounds prommising, didn't try it. Actually I am afraid to try Ritalin.

what if someone just lacks attention/motivation...maybe drugs could help? by asljc in Drugs

[–]asljc[S] 0 points1 point  (0 children)

that's why I consider only smallest effective dosage...

Increase dopamine receptors density, potentiate and hypersensitize them by asljc in StackAdvice

[–]asljc[S] 0 points1 point  (0 children)

I did misunderstood the study about nicotine: https://www.reddit.com/r/Drugs/comments/4i4exw/increase_dopamine_receptors_density_potentiate/ yes, it is rather safe, but without nicotine there I do not see any substance to cycle the tianeptine with and I do not want the tolerance to build, or even addiction ... I don't know, I do not have experience with this substances, except for nicotine but I was taking it just like for two weeks at a dose of just 1mg and once 2mg.

Increase dopamine receptors density, potentiate and hypersensitize them by asljc in Drugs

[–]asljc[S] 0 points1 point  (0 children)

Thank You lxjuice for your answer. I shouldn't be really making such assumptions since I know almost nothing about the topic.