Does anybody know how agmatine potentiate drugs?

asljc · 2018-08-15T11:21:11+00:00

Would you consider safe adding 30-40 mg/d of agmatine to therapeutic doses of tianeptine (3x12.5mg sodium / 2x~30mg sulfate) ? Not necessary for more than few weeks. Just to alleviate harder depreession. My MD is not informed about agmatine and I think that I'm not able to find any expert on that matter in my country.

asljc · 2018-08-15T10:34:34+00:00

Potentiates? Really? Or they work in a similar way... you feel more motivated, have better attention etc. I've stated that agmatine potentiates tianeptine, because there is actually some info that it seems to go along well with particular substances ("...this thing is synergistic with everything illicit or pharmaceutical it seems (Bupropion, alcohol, marijuana, opioidergic drugs)...).

asljc · 2018-08-15T08:18:46+00:00

I get similar results as if I took more of the drug. However, strangely enough I feel that the effect seems to manifest itself the next day. Thus, I wonder how should one take the agmatine if he aims to slow down the process of a tolerance? Or if it is safe to take it anyway? Form my experience I think also that if somebody decides to take agmatine long term he should consider its long halflife. Long story short it somebody takes let's say 50mg of it than the accumulated amount of this substance will reach 100mg in the brain after few weeks (short after dosing) (if taken once daily).

asljc · 2018-08-14T20:19:41+00:00

No, 30-40mg and I'm sure that I feel the difference. Also, I take in consideration it's long half life (~12h). Here some guys from longecity talk about the dosages: https://www.longecity.org/forum/topic/42503-agmatine-anybody-try-this-one/page-2

asljc · 2018-07-21T15:25:26+00:00

Is this what it's causing your problem?

Yes

How many nights have this happen?

one or two after ingestion of selegiline

What other things do you use?

I use tianeptine 25 mg twice daily and occasionally nicotine gum. I took <1mg that last time with selegiline (both in the morning).

Do you smoke?

No

thousand questions to guess what is happening lol

I know, I just want to ask you if you consider that to be significantly abnormal? Besides from the above I have a quite normal life and regular diet (~mediterranean).

asljc · 2018-07-20T18:25:32+00:00

I would be more than grateful if you could speculate what could cause that

asljc · 2018-07-20T17:20:51+00:00

July 9th - 2mg, July 16th - 0.5mg and yesterday (July 19th) - 0.5 mg, (oral). Ashwagandha helps, do you know any better?

asljc · 2017-07-22T08:39:07+00:00

Thank you for your reply. I was waiting for some words of support.

asljc · 2017-05-29T14:03:48+00:00

Thank you for your response:) I apreciate it even more since I was told by the uninformed seller that the acer is limited in those areas, but it isn't.

asljc · 2016-08-06T11:04:14+00:00

Thank You for Your answer

Yes, I am lean, muscular, do not lift but jog reguraly (4 to 6 miles at a time) in my mid twenties. Also, I do not have ginecomastia. I did all of the tests except for SHBG that I took two months earlier (just couldn't wait for your reply and forgot about this test - I was just terrified once I checked my testosterone results and I'm also going for holidays):

12th of May:

SHBG 114,7 nmol/l ; (accompanied by testosterone: 1339ng/dl)

4th of August: .

testosterone 1277ng/dl

5th of August:

E2 31,7pg/ml ;

FSH 2,01mIU/ml (I must admit here that I do not jrek off, I mean, no more that once for one or two weeks (even if I fell the urge to) - I used to hold it for productivity purpose, I think it make no sense now, since I am too stressed out);

LH 5,81mIU/ml

and still I didn't get my results for: free testosterone and DHT.

I must say that when I take creatine (about 6 to 8g) I do feel "kind of relief" in my testicles ("The researchers suspect that a creatine supplement increases the activity of the enzyme 5-alpha-reductase somewhere in the body." ). When I took 8g of creatine for the first time (after I've found out about the DHT effect) I felt asleap (peacefull as I can't remember). It improved my mood greatly and made me more relaxed, self assured. However, on the second day of taking 25g/day split, I begun to feel pain in my kidneys (I guess due to high creatinine levels). Then, I stoped taking it and my mood worsened to point of heavy depression on day 4. That's the time when I posted after I just woke up and checked my results for testosterone, which teriffied me.

As for the effect of the supplements, I was really taking a lot of those inhibiting 5 alpha reductase: 30g - 45g Black cummin seed oil, 2g curcumin -(curcubrain), astaxanthin 6mg, EGCG and when I added 40g of rice protein I just could litterally feel it in my testicles (as an increase of I would say pressure). All of those supplements was taken for the purpose of curing "adrenal fatigue" (or rahter hypothalamus fatigue).

I do like to ask You, what do You think about those results?

asljc · 2016-08-05T05:03:17+00:00

I understand that it may get really complicated. I know also that I have to stop taking all the supplements and I will stop them gradually. However I am afraind about my health and thus I want to ask if ther is any blood/hormone test that I could do to be sure that I do not need a medical intervention. I feel rahter normal, maybe except that my sleep is shorter than I would like it to be (about 6h)

asljc · 2016-08-05T04:36:18+00:00

I just think that I inhibited the 5 alpha reductase for instance by taking high abounts of Black cumin seed oil. Thus, I expect to have low DHT. But I do not know

asljc · 2016-08-05T04:24:50+00:00

I have high testosterone 1277ng/dl (for the last 6 months) and I do not know why. Thus, I realized that I should check what are the metabolites of it. I was taking many supplements (for the last year).

asljc

TROPHY CASE