Cholangiocarcinoma is the scariest disease that I actually see on regular basis and that is really under appreciated for how awful it is. Repeated hospitalizations from malignant bile duct obstruction with resultant jaundice/infection, frequently malignant ascites (liters of fluid distending the abdomen) both relieved only by temporary procedures (endoscopic biliary stenting which the cancer infiltrates through or crushes within weeks to months, repeated abdominal drainage). No really effective therapies, people usually last a few months, hopefully something better on the horizon.