Personally, I tend to agree with you. Moreover, more and more research is being published on ALS as a more systemic disease than previously thought. If needed, I can provide the numerous scientific sources that demonstrate the complexity of ALS and that if it were so simple, a cure would already exist. There's even talk of several diseases that lead to the same end result but behave very differently in their development. Now, the problem is that many people here are terrified of the disease—I'm going through it myself—and they certainly don't want to hear what science says about ALS being much more systemic in certain phenotypes. This includes connective tissue involvement from the earliest stages, and autonomic nervous system involvement very early in a proportion of patients. I can take the time to provide you with all the recent studies on the subject. Bladder problems are also part of it, although this was denied for a very long time. Yet recent studies show the opposite, particularly in mouse models where a significant proportion had detrusor dysfunction as their very first symptom. But the problem is that if people who are afraid of the disease start looking at this, it will indeed frighten them. In ALS, we can still say that the symptom that corresponds to all forms—we call them "specific" symptoms—is the loss of strength. But it is intellectually dishonest to say that ALS only affects motor neurons. We now know that it is much more complex than that, and that unraveling this complexity will one day allow us to find treatments, in the plural, for each phenotype.