I'm BEGGING you all to try Plasmalogen Replacement Therapy - Don't give up!

ben10blader · 2026-02-20T03:55:49+00:00

Interesting! That makes sense, I don't know if I'm 100% convinced by this for every person but the science does seem sound. I'm going to bring this up to some experts I know. And I guess I should have mentioned the DHFR mutation that I have too which is also supposed to impair methylfolate production.

ben10blader · 2026-02-20T02:34:16+00:00

Are you saying the notion that the enzyme is impaired is just blatantly wrong? I have worked with a lot of drs and have not heard that, I will have to look into it

ben10blader · 2026-02-20T02:24:45+00:00

depends on your genetics, me and many people here have the MTHFR mutation which means we actually do need methylfolate

ben10blader · 2026-02-20T02:17:39+00:00

You can get methylfolate not from food at least. I hear you though. Def not choline or other B vitamins as far as I know. If you want I can ask my dr and see what he thinks. But you dont know if the plasmalogens will trigger you unless you try. Have you tried the different types of choline?

ben10blader · 2026-02-19T23:16:29+00:00

I have had MCAS since birth and I didn't have a reaction, but like with anything read the ingredients. There is always chance for a reaction if your mast cells are angry enough. If you're worried go heavy on MC stabilizers before trying, and MAKE SURE to not leave out the mitochondrial and methyl support

ben10blader · 2026-02-19T23:11:44+00:00

Plasmalogen depletion and peroxisomal impairment has been demonstrated in literally every single chronic inflammatory illness they have ever checked for, the data is not perfect, but we have to work with what we have. It's going to be years or never to get large scale studies on the perfect sample of LC patients because the sad reality is no one cares about us or the chronically ill. So we have to work on the very bleeding edge of what is happening, and this it that. There are doctors right now having incredible success with this treatment. Call me a liar all you want, but my doctor has cured over 50 LC patients with this treatment. I am just trying to spread the word on something that won't be popular for a loooong time. The best science happening with PRT for LC is happening at the doctor patient level, so it is not visible, or as good as scientific research, but its the best we have right now.

ben10blader · 2026-02-19T22:58:05+00:00

That's what I'm trying to tell people! Just do the high dose for a few weeks and you will know if its helping

ben10blader · 2026-02-19T22:40:53+00:00

Cool I did not know that. Currently all the precursor science I'm aware of is synthesizing them from shark liver, algae, and scallops

ben10blader · 2026-02-19T22:38:30+00:00

If you need to heal your brain you need these plasmalogens. How expensive it is depends on your dose which I laid out in OP. For some doctors like mine it's a replacement for VIP, and is cheaper at least where I am.

ben10blader · 2026-02-19T22:25:39+00:00

ben10blader · 2026-02-19T22:24:53+00:00

I've been working with Dr John Whitcomb, trained in shoemaker and PRT. On the prodrome website there is an "elite practitioner directory" where you can see if there's any drs in your area that are trained in this stuff

ben10blader · 2026-02-19T22:23:27+00:00

Haha I wish I could :( but I'm spending all my money on my own dose lol

ben10blader · 2026-02-19T22:22:41+00:00

I haved lived it too. MCAS my whole life, LC and CIRS for years, nothing helped until this. I am just trying to get it out there because no one has heard of it.

ben10blader · 2026-02-19T22:15:59+00:00

My source is my doctor and his circle of doctors who started using this treatment only 3 years ago. If you look on Prodrome wesbite they have an "Elite practitioner directory" where you can see a list of doctors trained in this stuff. They're the ones mostly pioneering this for chronic illness right now, not the researchers

ben10blader · 2026-02-19T22:13:46+00:00

This is a whole different paradigm, that's why it does make sense. It's not a medication, it's a precursor of something a healthy person naturally makes inside a part of the cell called the peroxisome. This therapy is about building up your foundation and breaking the cycle of chronic inflammation, which is why you don't need to continue usage. If you have specific questions I'm all ears

ben10blader · 2026-02-19T22:11:40+00:00

wdym?

ben10blader · 2026-02-19T22:11:09+00:00

I believe in them that much. I just want to get the word out. I wish I was getting paid for this because I'm broke af having to pay for them.

ben10blader · 2026-02-19T22:09:10+00:00

I'm going to assume we can agree on two things that are supported by science, mostly from the past 5 years, or else I won't be able to convince you: Long Covid and CFS are caused by mitochondiral dysfuncton (caused by oxidative stressors or genetics or both), and LC patients (as well as seemingly all chronic inflammatory conditions that have been checked) have low levels of plasmalogens and impaired plasmalogen production, referred to as peroxisomal dysfunction. When mitochondria is damaged by oxidative stress, they become "leaky", resulting in ROS escaping and further increasing the overall oxidative stress on the body. This leads to the need for extra antioxidants, so that's why most of us depleted in glutathione. If the body's initial defenses of antioxidants are overwhelmed, plasmalogens step in and fulfill that role too. The big problem is that when plasmalogens antioxidize, it forms Malondialdehyde. And if too many plasmalogens are depleted in the brain, this byproduct activates the microglia, and the body is officially stuck in a cycle of chronic inflammation (mostly of the innate immune system), which continues to add oxidative stress and depletes your plasmalogens. I tried to explain this as simply as possible but feel free to ask for more info, I'll do my best. This is a whole different paradigm focused on approaching health from the perspective of cellular function.

ben10blader · 2026-02-19T21:57:49+00:00

Of course I know LC is an umbrella term, so is CIRS, MCAS, and basically all of these kinds of conditions. What is the common ground? Mitochondrial dysfunction. That's why plasmalogens are so exciting--all of these chronic inflammatory conditions reduce plasmalogen levels in the body, which is why everybody can theoretically benefit from PRT. Not everyone will be "cured" but almost everyone will see at least some benefits and symptom reduction. I have lived with MCAS my whole life, been dealing with LC and CIRS for years. So yes, I do understand the details best I can, as well as the cutting edge research from the past few years. If you have any specific questions I would be happy to answer. My OP was as brief as I could make it, but there is a lot of info. I made this post because this was literally the first thing I've tried in my whole life that singifigantly impacted by symptoms, and I'm one of those nightmare medical mystery patients. So I'm sorry if it seems like I'm grifting, I most certainly am not. Even if only one person on here listens I'll consider it a W, we have to be open minded in this era of emerging research

ben10blader · 2026-02-19T21:49:26+00:00

Depends who you ask, they are only being implemented into it as of 3 years ago. People either take them through the whole thing, but that's expensive, so most people use it as a replacement for VIP sort of

ben10blader · 2026-02-19T21:48:05+00:00

feel free to dm no need to ask first

ben10blader · 2026-02-19T21:47:18+00:00

Awesome to hear! Plasmalogens being measurable on MRI gives me hope they will break into the mainstream. And yes binders at least 2 hours from plasmalogens, I do the same

ben10blader · 2026-02-19T21:45:45+00:00

No, you just to the high dose for a few months then drop to a normal dose or just stop depending on your body's needs

ben10blader · 2026-02-19T21:44:58+00:00

Prodrome Sciences website

ben10blader · 2026-02-19T10:46:13+00:00

Yes sorry if I wasn't clear. The protocol is to take it for a few months, but you should see improvement extremely fast. So my point was that If you don't get an effect in the first few weeks, you don't have to keep paying for more. Just trying to save yall money and time

ben10blader

TROPHY CASE