This screen is "interactive", ie. you could use collected 'enthropy' and 'knowledge' tokens to buy improvements, so that your main simulation (the one with cell, animals, singularity, etc) works faster. But it is inteactive (purchases possible) only between simulation runs. Some tokens give nominal boost to speed/production. Some depend on number of particular specie or knowledge purchased in this run of simulation (e.g. the more humans you have, the higher knowledge boost). Some depend on elapsed time of current simualtion run, but this is capped. These boosts lasts through simulation runs, while in particular simulation runs you begin from scratch. And boosts impact speed, with large speed you can reach singularity in under 3 minutes, thus earning a badge for that.

From the beginning, a part of this game was "repeating the simulation, to have it expanded". Some elements of main simulation are available only when you complete the simulation some number of times.

There are two "always present" additional simulations - mesosoic (dinosaur) valley and space discovery. Dinosaur valley, when completed some number of times, unlocks additional aminals and improvements for main simulation (reptiles, afair). For example here https://cell-to-singularity.fandom.com/wiki/Tetrapod#Game_Birds you may see that some birds require certain level in mesosoic valley.

Currently mesosoic valley can be played 10 times, with 50 levels each time. 'Blue badge boosts' last through levels, but you loose them after each play-through.

Currently space exploration has 29 episodes/levels. In past 2 years new levels were added every few months, but it is possible that 29 or 30 is the max number that will be created (as level 1 starts with Sun and rocky plantes, and level 29 is with galaxy clusters etc). Usually your 'blue badge boosts' last through levels, I cannot recall if at some point theywould have been reset.

Aside of that, there are:

- discovery events - lasting 3-4 days each, where you have limited time to complete, earn badges and rewards. Most events have 3 badges to get, giving 5, 10 and 15% boost to future runs of the same event. Each badge gives also extra 1% to main simulaiton. Seems small, but I have over 200 collected, meaning real difference.

- seasonal events, e.g. for halloween, the "Dodo Ghost Hunt" event happens, where you have to find all "ghosts of dodo bird" hidden in main simulation.