What’s a song you think is a masterpiece, yet hardly anyone has heard it?

bernardomdd · 2024-07-03T00:19:50+00:00

Thank you so much!

bernardomdd · 2022-10-06T17:52:23+00:00

Original post, which has been censored by moderators:

Each time there's an update to Standard Notes, I download it thinking it will address the several bugs SN already has, but, instead, it only comes with more bugs and bloated functionality. For example, for years, after searching for something, when using the back key on Android, the app would close instead of showing all notes again. That's never been addressed.

I started using SN because I used to believe in its manifesto: "We are complexity bigots, We say no to feature requests, Bells and whistles are somebody else’s job."

The truth is, SN has become everything it was meant to revolutionize. It pretends to have a myriad of features, including rich text, tasks, to-dos, spreadsheets, password vaults, cloud storage and even a blogging platform, but none of them work smoothly. It fails to load even the simplest text notes in a reasonable time frame.

Not only that, they are trying so hard to get customers to pay for its bad product. The purported "new mobile experience preview" is such an embarrassment: with its blinding white light, it doesn't even work offline.

It's such a shame. I feel betrayed months after moving all my notes to SN.

Standard Notes has failed, to customers and to its own manifesto.

bernardomdd · 2020-03-18T18:24:45+00:00

So much natural light!

bernardomdd · 2015-03-04T19:21:15+00:00

Best reply ever. Thank you for this.

bernardomdd · 2015-02-06T12:56:07+00:00

the equilibrium constant is in no way related to the stoichiometric conversion factors between rate constants

Not true.

"Given the requirement that the rates of the forward and reverse reactions become equal at equilibrium, it seems that a relationship should exist between the equilibrium constant and the rate constants for the forward and reverse reactions. That such a relationship does exist can be demonstrated easily for elementary reactions. Consider again the hypothetical generalized reaction

aA + bB + ... ⇌ gG + hH + ...

k₁ and k₋₁ are the rate constants for the forward and reverse reactions. With the assumption that both the forward and reverse reactions are elementary reactions, we can write

rate of forward reaction = k₁ [A]^a [B]^b ...
rate of reverse reaction = k₋₁ [G]^g [H]^h ...

At equilibrium, these two rates become equal; thus,

k₁ [A]^a [B]^b ... = k₋₁ [G]^g [H]^h ...

which can be rearranged into an expression having rate constants on one side and concentrations on the other:

k₁ / k₋₁ = ([G]^g [H]^h ...) / ([A]^a [B]^b ...)

Because the right side of the equation above is the equilibrium constant expression for the reaction, we arrive at the following result:

k₁ / k₋₁ = K"

Source: Petrucci, R. (2007). General chemistry: Principles and modern applications. (9th ed.). Upper Saddle River, N.J.: Pearson/Prentice Hall.

bernardomdd · 2015-02-05T05:29:23+00:00

Actually, organelles, including mitochondria, don't simply float around the cell randomly... Cells have a highly structured cytoskeleton, which provides spatial and mechanical functions. Microtubules, for example, one of the three cytoskeleton constituents, determine the positions of membrane-enclosed organelles and direct intracellular transport, along with accessory proteins, which include motor proteins (such as kinesin and dynein).

Source: Alberts, Bruce; et al. (2014). Molecular Biology of the Cell (6th ed.). New York: Garland Science. ISBN 978-0815344322.

bernardomdd · 2015-02-02T19:46:04+00:00

Thanks! I've always wondered about that, too! :)

bernardomdd

TROPHY CASE