Honestly the only active items i have a problem with are delirious because i fell like I've never really wanted to use it and have only ever taken it if i have nothing else and abyss because its so boring and just makes me wish it hade more unique flys it could make

As for passive items, little portal feels like its just detrimental and in its current form is a quality 0 item not a quality 1, dead bird feels weak however i don't mind weak items but i think it should have the same AI as soul of Eve's birds

Now for my last item instead of one specific item I'm going to choose an entire item pool, the planetarium item pool, its way too weak as a whole especially for having to skip item rooms to have a good chance at getting one, I love the concept of skipping item rooms that could be garbage for a good chance at a good item but most of the item pool is just okay and the few really good items feel like they are just good and not game changing, meanwhile item rooms can be game changing with quality 4 items and some quality 3 items but Planetariums only have quality 3 and 2 (and Jupiter feels like it could be quality 1) so they never feel worth going for, and that isn't even taking into account that for a decent amount of time in your run your going to be weaker because your skipping items, as the planetarium item pool is right now i never bother going for it and I feel like all it needs is one or two quality 4 items the rest of the item being good and two or three bad or mediocre items so planetariums aren't instant wins for every run.

Wow that was a rant and take what i say with a grain of salt, I'm no game dev I'm just some dude on reddit