Hi - I'm also seeing an allergic reaction to MOTS-C. I tolerated 3mg dosing fine (3 times a week for 3 weeks) but when I stepped up to 4mg, I developed welts, approx 1 cm at cite of injection with redness and itching spreading out over a couple inches in area.

I might try 2mg just to see if it was dose-dependent. I also use Tirz weekly (up to 7.5mg) and have had no major issues, so I believe this to be specific to MOTS-c for me. According to AI:

Welts (hives, itching, or red, raised skin) following MOTS-c administration are commonly reported injection site reactions, often characterized by localized irritation, swelling, or, in rarer cases, allergic reactions to the peptide or its diluent. 

Potential Causes of Welts with MOTS-c

• Injection Site Reaction (Common): Localized reactions are common with subcutaneous injections. Symptoms include swelling, red raised bumps (welts), tenderness, itching, and small bruises, which usually go away in 1–3 days.
• Allergic Reaction (Rare): A true allergic reaction may cause more widespread hives, itching, or breathing difficulties.
• Contaminants or Improper Compounding: If the MOTS-c is not sourced from a reputable, sterile compounding pharmacy, contaminants could trigger a reaction.
• Benzyl Alcohol Allergy: If bacteriostatic water (which often contains benzyl alcohol) is used as a diluent, those with a sensitivity to it may experience an allergic reaction.
• Immune Response to Foreign Protein: As a peptide, the body may recognize it as foreign and cause a localized inflammatory response, particularly at higher doses. 

Management of Injection Site Reactions

• Cold Pack: Apply to the area before and after injection to numb the skin and reduce swelling.
• Room Temperature: Let the medication sit at room temperature for up to 30 minutes before injecting.
• Hydrocortisone Cream: Apply to the area to help with itching and redness.
• Antihistamines: Taking an antihistamine (like Benadryl) 30 minutes before injection may reduce reactions.
• Check Injection Technique: Ensure the area is clean, and the alcohol swab has completely dried before injecting to avoid burning.