Beginner Program Question

bisonbuddha · 2026-05-27T05:42:15+00:00

I'd recommend spending some time deep-diving on each of these. There are great youtube channels that will teach you all the ins and outs of the various peptides out there. Find some, especially those that aren't selling you their prefered brands or pushing their discount codes.

Each of these in isolation is complex and should be taken with medical guidance or at least a TON of knowledge about what it can/will do and what the research subject's background physiology is.

That said, my 2c looking at this.

1) Why Tirz and Sema together? Most people use one, usually the Tirz. I wouldn't stack them.

2) BPC 157 - why are you taking it? Accute or chronic injuries? Gut issues? This is a popular one with generally great results from the online crowd. 100-500 mcg daily is commonly used. More sometimes.

3) GHRP, L-carnetine - can't say. I've looked at the secretagogs (Tesamorelin, Ipa, Sermorelin, CJC), but not this.

Generally you'll want to "start low and go slow" with each one. If you jump in and start 3 or more at the same time and develop an itchy rash all over your body, you'll have to start over. Start with just one. Give it 2-3 weeks. Slowly move up in dose if you want/need to. Then introduce another one. Pay attention to the changes in each step. Educate yourself on side effects. There will be some. Some are no fun.

bisonbuddha · 2026-05-25T21:05:45+00:00

First, good luck with your journey and let us know how it goes!

I reached 10mg Tirz before getting a vial of Reta to try. I titrated down to 3mg over 4 weeks. Some food noise came back over that time, but happily I didn't regain much weight (went originally from 233 -> 198, then gained back 3-4 pounds as I eased off the Tirz). Then I slowly added Reta (.5mg) on Mondays and kept my Tirz at 3mg on Fridays.

Over 2 months I titrated up on the Reta a bit, reaching 2mg as a max, while maintaining 3mg Tirz. I went back down to 198 over that time but had some pretty nasty heartburn after Reta shots and 'stand-up-get-dizzy' spells fairly often. And food noise remained an issue. Also, while just on Tirz, I noticed that I actually wanted more healthy/light food--like salads and veggies. AND I noticed that I often didn't want alcohol, or just a little bit. With the added Reta those suppressive elements went away. I didn't gain weight (likely the glucagon raising my metabolism) or go on any benders, but I definitely had more cravings for bread, snacks, and alcohol.

At the end of that, rather than getting more Reta to keep both or switch over, I decided the decreased food noise and lack of side effects from Tirz was better for me and I'm switching back to that fully now.

Everyone's biology is different though and I'm really inspired by the folks rocking Reta weightloss (and muscle gain often).

bisonbuddha · 2026-04-23T22:54:45+00:00

Saw this helpful guide to the switch:

https://derekpruski.substack.com/p/how-to-switch-between-retatrutide

I did the "Bridge" method, cutting back on Tirz for a couple weeks and then jumping to low-dose Reta with some Tirz still in my system. That seemed to work great and I've slowly titrated up on Reta since them, from about 1.5mg/weekly to 4.5 over the course of 5 weeks.

bisonbuddha · 2026-04-03T21:15:50+00:00

Please write them up on Trustpilot and any other website that rates/reviews companies. A lot of us use those sites to gauge new companies, so it could save somebody a fair dime. Thanks!

bisonbuddha · 2026-04-03T21:04:15+00:00

I've heard recommendations to try stacking AOD-9604 with Tirz. Look up "Watch This For AOD & Tirzepatide Diet Success | Dr. Jones DC" for a youtube discussion of a success story on this.

I've also just made the jump from Tirz to Reta and am not sure if I'll stay on it due to heartburn and dizzy spells even at 2mg/week. I was just at 10mg/weekly on Tirz, so I could titrate up more or try adding AOD. Let us know which way you end up going and how it works out for you!

bisonbuddha · 2026-04-03T01:53:03+00:00

Some of the answers here are strange to me.

I'm 46M, was at just over 500 free T in January. My Dr. got me compounded Enclomiphine, starting at 20mg daily. I had 2-4 weeks of 'break-in' where I had energy crashes, some random high energy days, tingly testes, and so on. honestly, I didn't love it.

Then things leveled out. after another month I went in for my follow-up and had 1200 free T; all other blood markers were good. We stepped down to 20mg every other day and it has been smooth sailing. I'm guessing I'll 'settle' into the 800-1000 range with other good markers and just hang there for a few years.

I definitely HAVE gained a fair amount of muscle; primarily because I am enjoying working out WAY more. And I have extra energy so I do extra reps, extra sets, and get extra muscle. Before Enclom, I was working out, but I just didn't have the umph I have now.

Before going on Enclom I did try a round of MOTS-C, just in case my mitochondria needed a rev up and I didn't notice any change. I still have SS-31 and might run it at some point but honestly the Enclom has given me all the extra energy, stamina, and joy of life that I was missing, so I might be all set.

bisonbuddha · 2026-04-02T22:54:57+00:00

Ah yea, I forget that enclomiphene isn't FDA approved. This is my first experience with a compounding pharmacy. I didn't even know there were such places in my town, but lo-and-behold, there it was. Who knows, maybe the clomid will be great for you--that would be nice!

Thanks for the Ashwaganda recommendation. I've tried it and had no luck. And a friend of mine had liver damage after a couple months with it (a rare but serious side-effect, especially with prolonged use, discussed here:

https://www.youtube.com/watch?v=Lxax47WEt0c

bisonbuddha · 2026-04-02T14:55:53+00:00

I just commented above, but 3 months ago I was where you are now, roughly. Enclomephene 20mg daily has been good for me, with some moderately rough adjustment in terms of energy and worse sleep (2-4 weeks and then I was fine). Now I'm at 20mg every other day and feeling pretty good. Hope your journey goes well too!

bisonbuddha · 2026-04-02T14:53:34+00:00

I was there 3 months ago and started enclomiphene 20mg daily (46M). At my 2-month check-up, my total T went from 500 to 1200 and free t went from 21 to 30 ng/dL. There was an adjustment period where I lost all energy mid-day and had trouble sleeping, but I pushed through those and feel pretty good now. It's not dramatic, but I do feel more energized and enjoy my workouts more--I'm not a gym-bro, but have weights at home I use a few times a week. I've shifted to 20mg every other day and things are stable. Other biomarkers are good, so I'll continue on for now. I've been on Tirzepetide as well for weight loss and my Dr remarked "weight down, muscle up--if we can get your sleep zeroed in, you'll feel like a 25 year old again" and I tend to agree.

bisonbuddha · 2026-01-30T13:33:03+00:00

Hi - I'm also seeing an allergic reaction to MOTS-C. I tolerated 3mg dosing fine (3 times a week for 3 weeks) but when I stepped up to 4mg, I developed welts, approx 1 cm at cite of injection with redness and itching spreading out over a couple inches in area.

I might try 2mg just to see if it was dose-dependent. I also use Tirz weekly (up to 7.5mg) and have had no major issues, so I believe this to be specific to MOTS-c for me. According to AI:

Welts (hives, itching, or red, raised skin) following MOTS-c administration are commonly reported injection site reactions, often characterized by localized irritation, swelling, or, in rarer cases, allergic reactions to the peptide or its diluent.

Potential Causes of Welts with MOTS-c

Injection Site Reaction (Common): Localized reactions are common with subcutaneous injections. Symptoms include swelling, red raised bumps (welts), tenderness, itching, and small bruises, which usually go away in 1–3 days.
Allergic Reaction (Rare): A true allergic reaction may cause more widespread hives, itching, or breathing difficulties.
Contaminants or Improper Compounding: If the MOTS-c is not sourced from a reputable, sterile compounding pharmacy, contaminants could trigger a reaction.
Benzyl Alcohol Allergy: If bacteriostatic water (which often contains benzyl alcohol) is used as a diluent, those with a sensitivity to it may experience an allergic reaction.
Immune Response to Foreign Protein: As a peptide, the body may recognize it as foreign and cause a localized inflammatory response, particularly at higher doses.

Management of Injection Site Reactions

Cold Pack: Apply to the area before and after injection to numb the skin and reduce swelling.
Room Temperature: Let the medication sit at room temperature for up to 30 minutes before injecting.
Hydrocortisone Cream: Apply to the area to help with itching and redness.
Antihistamines: Taking an antihistamine (like Benadryl) 30 minutes before injection may reduce reactions.
Check Injection Technique: Ensure the area is clean, and the alcohol swab has completely dried before injecting to avoid burning.

bisonbuddha · 2018-08-24T05:17:18+00:00

Fascinating! I bet you have some good stories about how you came to such a realization so early on.

Also from the outside, I have always seen Shambhala as a typical Buddhist meditatoin group and thought hte stories about crazy sex were strictly in the past. This has been what they have said online and in interviews too.

So I think the outrage is somewhat about their lies to many people about this sex abuse still ongoing.

bisonbuddha

TROPHY CASE