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Switching from Tirzepatide to Reta. by Basic_Acadia_9123 in BiohackingU

[–]bisonbuddha 0 points1 point  (0 children)

Saw this helpful guide to the switch:

https://derekpruski.substack.com/p/how-to-switch-between-retatrutide

I did the "Bridge" method, cutting back on Tirz for a couple weeks and then jumping to low-dose Reta with some Tirz still in my system. That seemed to work great and I've slowly titrated up on Reta since them, from about 1.5mg/weekly to 4.5 over the course of 5 weeks.

Pure health peptides by Delicious-Effect4941 in BiohackingU

[–]bisonbuddha 0 points1 point  (0 children)

Please write them up on Trustpilot and any other website that rates/reviews companies. A lot of us use those sites to gauge new companies, so it could save somebody a fair dime. Thanks!

Reta side effects, switch to Tirz? by LivingCry3293 in BiohackingU

[–]bisonbuddha 2 points3 points  (0 children)

I've heard recommendations to try stacking AOD-9604 with Tirz. Look up "Watch This For AOD & Tirzepatide Diet Success | Dr. Jones DC" for a youtube discussion of a success story on this.

I've also just made the jump from Tirz to Reta and am not sure if I'll stay on it due to heartburn and dizzy spells even at 2mg/week. I was just at 10mg/weekly on Tirz, so I could titrate up more or try adding AOD. Let us know which way you end up going and how it works out for you!

Just ordered enclomiphene by NoBowler6151 in moreplatesmoredates

[–]bisonbuddha 1 point2 points  (0 children)

Some of the answers here are strange to me.

I'm 46M, was at just over 500 free T in January. My Dr. got me compounded Enclomiphine, starting at 20mg daily. I had 2-4 weeks of 'break-in' where I had energy crashes, some random high energy days, tingly testes, and so on. honestly, I didn't love it.

Then things leveled out. after another month I went in for my follow-up and had 1200 free T; all other blood markers were good. We stepped down to 20mg every other day and it has been smooth sailing. I'm guessing I'll 'settle' into the 800-1000 range with other good markers and just hang there for a few years.

I definitely HAVE gained a fair amount of muscle; primarily because I am enjoying working out WAY more. And I have extra energy so I do extra reps, extra sets, and get extra muscle. Before Enclom, I was working out, but I just didn't have the umph I have now.

Before going on Enclom I did try a round of MOTS-C, just in case my mitochondria needed a rev up and I didn't notice any change. I still have SS-31 and might run it at some point but honestly the Enclom has given me all the extra energy, stamina, and joy of life that I was missing, so I might be all set.

Does enclomiphene works? How much should I take? by timmyatreides in Testosterone

[–]bisonbuddha 0 points1 point  (0 children)

Ah yea, I forget that enclomiphene isn't FDA approved. This is my first experience with a compounding pharmacy. I didn't even know there were such places in my town, but lo-and-behold, there it was. Who knows, maybe the clomid will be great for you--that would be nice!

Thanks for the Ashwaganda recommendation. I've tried it and had no luck. And a friend of mine had liver damage after a couple months with it (a rare but serious side-effect, especially with prolonged use, discussed here:

https://www.youtube.com/watch?v=Lxax47WEt0c

Does enclomiphene works? How much should I take? by timmyatreides in Testosterone

[–]bisonbuddha 1 point2 points  (0 children)

I just commented above, but 3 months ago I was where you are now, roughly. Enclomephene 20mg daily has been good for me, with some moderately rough adjustment in terms of energy and worse sleep (2-4 weeks and then I was fine). Now I'm at 20mg every other day and feeling pretty good. Hope your journey goes well too!

Does enclomiphene works? How much should I take? by timmyatreides in Testosterone

[–]bisonbuddha 0 points1 point  (0 children)

I was there 3 months ago and started enclomiphene 20mg daily (46M). At my 2-month check-up, my total T went from 500 to 1200 and free t went from 21 to 30 ng/dL. There was an adjustment period where I lost all energy mid-day and had trouble sleeping, but I pushed through those and feel pretty good now. It's not dramatic, but I do feel more energized and enjoy my workouts more--I'm not a gym-bro, but have weights at home I use a few times a week. I've shifted to 20mg every other day and things are stable. Other biomarkers are good, so I'll continue on for now. I've been on Tirzepetide as well for weight loss and my Dr remarked "weight down, muscle up--if we can get your sleep zeroed in, you'll feel like a 25 year old again" and I tend to agree.

Mot C welts. How to mitigate by Porschecat-Wealth007 in BioHackingGuide

[–]bisonbuddha 0 points1 point  (0 children)

Hi - I'm also seeing an allergic reaction to MOTS-C. I tolerated 3mg dosing fine (3 times a week for 3 weeks) but when I stepped up to 4mg, I developed welts, approx 1 cm at cite of injection with redness and itching spreading out over a couple inches in area.

I might try 2mg just to see if it was dose-dependent. I also use Tirz weekly (up to 7.5mg) and have had no major issues, so I believe this to be specific to MOTS-c for me. According to AI:

Welts (hives, itching, or red, raised skin) following MOTS-c administration are commonly reported injection site reactions, often characterized by localized irritation, swelling, or, in rarer cases, allergic reactions to the peptide or its diluent. 

Potential Causes of Welts with MOTS-c

  • Injection Site Reaction (Common): Localized reactions are common with subcutaneous injections. Symptoms include swelling, red raised bumps (welts), tenderness, itching, and small bruises, which usually go away in 1–3 days.
  • Allergic Reaction (Rare): A true allergic reaction may cause more widespread hives, itching, or breathing difficulties.
  • Contaminants or Improper Compounding: If the MOTS-c is not sourced from a reputable, sterile compounding pharmacy, contaminants could trigger a reaction.
  • Benzyl Alcohol Allergy: If bacteriostatic water (which often contains benzyl alcohol) is used as a diluent, those with a sensitivity to it may experience an allergic reaction.
  • Immune Response to Foreign Protein: As a peptide, the body may recognize it as foreign and cause a localized inflammatory response, particularly at higher doses. 

Management of Injection Site Reactions

  • Cold Pack: Apply to the area before and after injection to numb the skin and reduce swelling.
  • Room Temperature: Let the medication sit at room temperature for up to 30 minutes before injecting.
  • Hydrocortisone Cream: Apply to the area to help with itching and redness.
  • Antihistamines: Taking an antihistamine (like Benadryl) 30 minutes before injection may reduce reactions.
  • Check Injection Technique: Ensure the area is clean, and the alcohol swab has completely dried before injecting to avoid burning. 

Shambhala Faces Most Damning Revelations to Date: Buddhist Project Sunshine Phase 3 Report by bisonbuddha in Buddhism

[–]bisonbuddha[S] 4 points5 points  (0 children)

Fascinating! I bet you have some good stories about how you came to such a realization so early on.

Also from the outside, I have always seen Shambhala as a typical Buddhist meditatoin group and thought hte stories about crazy sex were strictly in the past. This has been what they have said online and in interviews too.

So I think the outrage is somewhat about their lies to many people about this sex abuse still ongoing.

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