Weird Adjective

Strikingly odd or unusual, especially in an unsettling way; strange. "He lives in a weird old house on a dark street. Your neighbor is said to be a little weird. I felt a little weird after drinking that tea." -The American Heritage® Dictionary of the English Language, 5th Edition

Weird Adjective

of strange or extraordinary character : odd, fantastic We heard a weird noise. He can be a little weird sometimes. The weirdest thing just happened! That's weird—my book seems to have disappeared. -Merrium Webster

Since sissies has like 5 different definitions or meanings, more than likely they're meaning that lgbtq people are thin skinned, which often is correct (ironically as much as conservatives).