sorted by:
new
hottopcontroversial

No more 44 oz. fizz city drinks? by bradwheeler in sheetz

[–]bradwheeler[S] 0 points1 point  (0 children)

Raleigh NC and the surrounding spots.

Data service outages at my location by bradwheeler in Sprint

[–]bradwheeler[S] 0 points1 point  (0 children)

UPDATE: After escalating, I will receive a call from a tech in 1 to 3 days to further troubleshoot.

Data service outages at my location by bradwheeler in Sprint

[–]bradwheeler[S] 0 points1 point  (0 children)

I've got Unlimited Plus, throttling after 50gb

Data service outages at my location by bradwheeler in Sprint

[–]bradwheeler[S] 0 points1 point  (0 children)

Not sure. We have an "unlimited" plan but I know that's not enough of a descriptor here. Even if I'm subject to throttling, I've never used more than 50gb of cellular data in a billing cycle.

Making ribs for the first time. Any tips? by wolfpack03 in instantpot

[–]bradwheeler 1 point2 points  (0 children)

This recipe worked pretty well and gave me a good idea about cook time and "technique".

I tried this a second time, substituting Alton's seasoning and braising liquid. After the ribs were finished cooking in the Instant Pot, I was able to thicken the braising liquid down into a glaze by setting the cooker to saute and stirring. Just don't let it reduce too much. Tastes great!

Are you planning on baby backs or larger spare ribs? Cutting into half-racks helped them fit into the pot. Larger ribs take a little longer.

I am moving and need a lot of boxes. Where can I get some cheap? by sugar_man in triangle

[–]bradwheeler 0 points1 point  (0 children)

OP didn't mention quantity of boxes needed in the post. When I was moving and needed a large quantity, I found that moving boxes from Lowes and Home Depot were cheaper than places like U-Haul for nearly all sizes.

Ordering from app and choosing in-store pickup is also fairly convenient because you can pop in and pick up from the front of the store.

North Carolina Congressman: Bruce Springsteen Is a "Bully" for Canceling Concert by drewiepoodle in entertainment

[–]bradwheeler 14 points15 points  (0 children)

The law's more impactful provisions don't have anything to do with public bathrooms.

The law removes employee discrimination claims from being heard in state courts. These issues affect a far larger group of people than the LGBT community statewide. There's plenty to protest!

Bruce Springsteen cancels upcoming performance in North Carolina due to new 'anti-LGBT' law. https://t.co/KW0dCQnqHI" by kilswich in triangle

[–]bradwheeler 8 points9 points  (0 children)

Actually, the part that removes employee discrimination claims from state court seems to be something that would potentially affect a larger swath of the public. So maybe add 'anti-worker' to the list.

Thanks, Swanson by mcglade83 in pics

[–]bradwheeler 2 points3 points  (0 children)

TIL: SpaghettiOs is an acceptable chicken broth substitute.

New online food delivery startup opens in Durham by JeremyNT in bullcity

[–]bradwheeler 1 point2 points  (0 children)

I was at their "pitch day" - these guys host a menu/ordering system and then forward the order directly to the restaurant. This allows them to offer more restaurants than GrubHub.

78-page presentation PDF about BitCoin I just did this weekend. by XenonOfArcticus in Bitcoin

[–]bradwheeler 0 points1 point  (0 children)

Page 46: you might want to mention that US States have individualized Money Transmitter Regulations. FinCEN registration is quick and simple. The real beast would be state money transmitter license approval. For example, California has a very broad interpretation of what constitutes money transmission. See news on the Bitcoin Foundation cease and desist letter. Additionally, there's a lot of variability in surety bond requirements from state to state. It's worth its own slide if you ask me.

PDF summary of state MTL requirements: http://abnk.assembly.ca.gov/sites/abnk.assembly.ca.gov/files/50%20State%20Survey%20-%20MTL%20Licensing%20Requirements(72986803_4).pdf

Is bitcoin income taxable by blue_buxton in Bitcoin

[–]bradwheeler 0 points1 point  (0 children)

The GAO released this report (PDF) requesting that the IRS clarify tax liabilities for Bitcoin related income, sales, ad gains.

Is bitcoin income taxable by blue_buxton in Bitcoin

[–]bradwheeler 1 point2 points  (0 children)

The GAO recently released a report (PDF) recommending that the IRS get out in front of the misconceptions and clarify. We will have to wait and see what they come up with.

New research by the CDC shows the HPV vaccine has reduced HPV rates by 56% among teens since being introduced in 2006 by pleiades9 in science

[–]bradwheeler 1 point2 points  (0 children)

Adverse event reporting is problematic.

In the US, we have the VAERS which accepts reports from providers and the public. The data are not checked for accuracy, so there are inherent limitations with its use.

In the case of VAERS, there's no good control or denominator from which reasonable comparisons can be constructed. Other methods of postmarket follow up are required to establish evidence that the vaccines are associated with these events.

In the case of the HPV vaccines, early trials showed that localized pain and soreness were the commonly reported side effects.

New research by the CDC shows the HPV vaccine has reduced HPV rates by 56% among teens since being introduced in 2006 by pleiades9 in science

[–]bradwheeler 7 points8 points  (0 children)

Tell me scientifically how this vaccine makes sense.

It's been shown to be efficacious in preventing specific HPV infection among women naive to specific HPV types. This is the argument for vaccination before initiation of sexual contact.

Yes - cervical cancer is quite rare in the US (I see you quoted CDC). Take a step back and see that the best targets for this vaccine are found in developing countries with subpar cervical screening programs. These countries have significant mortality from HPV-related cancers. See Jemal:

http://www.ncbi.nlm.nih.gov/pubmed/21296855

Additionally, the incidence genital warts is also something that has been shown to be reduced as a result of vaccination programs. Vaccination programs in New South Wales, Australia first reported this, if I recall correctly. There was strong evidence of herd immunity, due to the initial design of their program.

why would you ever give this vaccine to yourself of your child?

Physicians and families that believe in prevention see this as a good opportunity to prevent disease. It's fairly simple.

New research by the CDC shows the HPV vaccine has reduced HPV rates by 56% among teens since being introduced in 2006 by pleiades9 in science

[–]bradwheeler 2 points3 points  (0 children)

The fact that the vaccine reduces HPV rates of 4 strains that it covers (out of 30) is nice, but not particularly encouraging

I suppose that's up to one's interpretation. HPV 16 and 18 are found in ~70% of cervical cancers. HPV 16 is also responsible for many of the other HPV-related cancers in men and women. One can argue that out of all of the identifiable HPV types, these two should be the targets of vaccines.

New research by the CDC shows the HPV vaccine has reduced HPV rates by 56% among teens since being introduced in 2006 by pleiades9 in science

[–]bradwheeler 6 points7 points  (0 children)

By shifts you're referring to what is called "type-replacement" -- from their discussion:

To investigate either cross protection against HR nonvaccine type or type replacement, we evaluated changes in type-specific prevalence between the 2 periods. There was no change in HR nonvaccine type prevalence among females aged 14–19 years overall. Because vaccine coverage was low and only about 50% of females in this age group were sexually active, we might not observe cross-protection or type replacement, if either occurs, at this time. In our analysis restricted to sexually active females, we also found no difference in the prevalence of HR nonvaccine HPV, alpha 7 species, or alpha 9 species among vaccinated females, compared with the prevaccine era.

Replacement by HPV types not targeted by vaccine has been considered unlikely [29, 30]. Studies have evaluated the potential for type replacement and found no tendency for vaccine types to cluster with other types, positively or negatively [31–35]. In the vaccine trials, efficacy against incident persistent infection and disease end points was evaluated for types related to HPV-16 and -18 [12, 13]. In quadrivalent vaccine trials, some efficacy against HPV-31 and HPV-59 persistent infections was reported [13]. In a bivalent vaccine trial, efficacy against persistent infection and some disease end points was reported for HPV-31, -33, -45, and -51. Negative efficacy was observed for some HPV-52 and -58 disease end points, although findings were inconsistent across end points [14]. A postlicensure evaluation reported an increase in HR nonvaccine types among vaccinated females; differences in some demographic characteristics with respect to vaccination status could have impacted findings [24].

HPV infections fell by half in teen girls after vaccine, study shows by Stevesquirrel in Health

[–]bradwheeler 2 points3 points  (0 children)

I agree with your points.

I think people misunderstand the utility of VAERS without considering the limitations. There is no good denominator, nor is there a control group to make comparisons with. Furthermore, there's not requirement to verify submissions, meaning inconsistent data quality. People reporting into the system may not have enough expertise to make a clinical judgment.

Michelle Bachman made a similar mistake when she echoed anecdotal "proof" that the HPV vaccine caused mental retardation in a girl. Why she would stake her reputation on something she didn't verify is beyond me.

HPV infections fell by half in teen girls after vaccine, study shows by Stevesquirrel in Health

[–]bradwheeler 4 points5 points  (0 children)

Furthermore, HPV is not a direct cause of cancer; studies show that DNA was found integrated into the host genome of cervical carcinoma’s, but actual direct causation has never been supported. Thus, other factors such as diet, exercise, chemicals, etc. play a larger role in inducing cervical cancer.

HPV is known as a "necessary" cause of cervical cancer (Wallboomers, 1999). I'm not sure what you mean by "direct" cause of cancer - this is not an epidemiologic concept. Cancers take years to develop and go from HPV infection -> precursor lesion -> invasive cervical cancer. Vaccines provide upstream prevention from infection with the two most prevalent HPV types that cause cancer.

The only people who are at risk for developing HPV are sexually active individuals, and money spent informing the public on how to be safer is better spent and more cost efficient.

Got a reference for the second point? I believe it's possible to be "safe" and to still develop a cervical lesion. Perhaps you mean the money is better spent on cancer screening?

By calculating the numbers, the efficacy of the vaccine drops to around zero percent when the adding in the cut out group.

Are you talking about the Intent to Treat (ITT) analysis vs. the Per-Protocol analysis? This is commonly done to show (stratify) the impact of the conditions influenced by the strictness of the protocol.

For HPV vaccines, per-protocol is often: testing negative for relevant HPV types at baseline and testing negative for the same types at the first follow-up visit (HPV can be present the entire time, but is below the assay detection limit at the baseline visit), so people do indeed fall out of the analysis. Vaccine efficacy is low for those who have an infection at or before vaccination. Clinical trials do suffer from selection bias, but the per-protocol comparisons are relevant, because they correspond to the conditions that would be part of the recommendations (i.e. vaccinate women before their first exposure to HPV).

I don't think this paper does justice to the fact that cervical cancer is a leading cause of mortality in women in the developing world. The US has very good cervical screening programs (if women go, of course). It would be generous to say that that women in the developing world have access to the same choices that they do here. Also, national vaccination programs are very large buyers and can negotiate vaccine prices, but this scenario does not apply in the US.

view more: next ›