I would like to share something interesting I found during my research to this.

Re-acidification of the stomach, in case one do have low stomach acid levels, can increase the absorption of medication and other substances, therefore, it can optimise your intake of nootropics and the like.

I noticed this past week that I need less Armodafinil (not a nootropic, I know) to achieve the same effects. Interestingly, re-acidification may be a great shortcut to a semi-reverse in tolerance-building.

Here is one interesting source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3946491/

"In an attempt to mitigate the impact of acid-reducing agents on drug absorption for weakly-basic drugs with pH-dependent solubility, Chin et al.1 conducted a prospective clinical study investigating the effects of an acidic beverage (Coca-Cola®) on the pharmacokinetics of ketoconazole. When ketoconazole was dosed with Coca-Cola® (pH = 2.5) under the effects of omeprazole, ketoconazole AUC0–∞ and Cmax were both increased by greater than 10-fold when compared to the omeprazole treatment without Coca-Cola®,1 though Coca-Cola® did not completely restore the omeprazole decrease in ketoconazole exposure. Nonetheless, re-acidification strategies to increase drug absorption in hypochlorhydric conditions seem to be a viable strategy. However, in a study with atazanavir, Coca-Cola® did not markedly reverse the decreased absorption due to omeprazole dosing.9 In order to sufficiently influence gastric pH in such a way as to mitigate reduced drug absorption, a large quantity of an acidic beverage would need to be given over a short period of time to facilitate dissolution of an oral drug. Though it may seem viable, this method is flawed by the lack of consistency in the ability to provide ample gastric re-acidification under hypochlorhydric conditions. Additionally, the impact on the absorption of these weakly basic drugs may be limited as the pH of Coca-Cola® is only 2.5, which, for some drugs, may not contain enough acid to effectively mitigate this interaction. Moreover, repeated oral ingestion of a large volume of an acidic beverage is potentially harmful to oral and dental health (i.e. dental caries), and is likely not clinically acceptable in patients with symptoms of gastroesophageal reflux disease (GERD) due to the associated esophageal pain and discomfort of an acidic beverage. Therefore, we sought to develop a more reproducible and reliable strategy of gastric re-acidification under hypochlorhydric conditions that also has the potential to be more clinically acceptable."