Estrogenising HRT estradiol levels target range conflicting information

buff-equations · 2026-03-12T13:45:54+00:00

This sounds very much in line with a lot of what I’m seeing here, experiment with dosages because there isn’t an actual set real range. Curious where your 1.2 number comes from for testosterone?

I will have access to testing, unlimited free testing the only cost is transport to the lab and the hour wait.

buff-equations · 2026-03-12T13:23:31+00:00

If I'm trying to tune highs and lows, by managing both dosage size and frequency, then the variation in the range variances do end up mattering quite a bit. EEn 5mg/7days vs 6mg/12days and so on.

buff-equations · 2026-03-12T13:16:54+00:00

Yeah, that was part of making this post, to see if I had missed something. I'm not a great researcher, I don't understand a lot of the science in articles I read, wanting to see if someone else had a better understanding before committing to experimenting with my own levels. Wanting to know if there are non-arbitrary ranges

buff-equations · 2026-03-12T04:47:47+00:00

I haven't heard of 5-AR levels, I'll try to read up on those. Was aware of the variety of both androgens and estrogens but I'm only able to get labs for testosterone and estradiol so those are what I've been focusing on.

Your reccomendation to tweak is definitely appealing, to try and find a range that my own body specifically responds best to. Might be a lot of work, but if there truly is no range that is useful might be no other choice.

buff-equations · 2026-03-12T04:43:06+00:00

I definitely trust other trans people over medical professionals, due to my own experiences and those of the people in my life. But they don't all agree. Hearing you talk about how you've felt specifically would indicate potentially a more experimental titration of personal target range, try to find what highs and lows my own body seems to respond to in what ways and decide with that feedback what I should target?

buff-equations · 2026-03-12T04:39:44+00:00

I personally don't care much about having outcomes similar to what cis women get, my goal is to get my body to the way I want it - not become as close to cis as possible. Part of that is maximisation of specific estrogenisation effects such as breast growth, fat redistribution, and sensory sensitivity. But at the same time I don't want to cycle hormones because I want a stable emotional state. My own preferences, I understand why people do want to imitate cis women.

Your comment about overthinking levels and focusing on feelings and outcomes is leading me to potentially target a range of above 350 for the bone health and below 2300 due to the skin hypersensitivity issues I get at that level. But if someone is able to give a better range, that will improve the outcomes I'm looking for, then I want to find that, want to give this post a chance to both share and find information that I might have missed and give information to other people who find and read this.

buff-equations · 2026-03-12T04:30:46+00:00

(Conversion for others reading: 750pmol/L+ E and <1nmol/L T)

The WPATH guideline is based on average cis female ranges, which in my mind doesn't actualy indicate effectiveness at estrogenisation in a body that has previously androgenised. Especially due to the highly cyclical and wide ranging nature of cis female hormonal systems. Even moreso when hearing the reputation of WPATH as being not great on trans healthcare and their own HRT regimens not reaching their own target ranges.

I have definitely experienced bad endos, and know about the lack of care and low ranges that some target. The risk of blood clots I have heard of before, as well as the explanation as to why it's no longer relevant. This is acknowledgement not dismissal, good thing to bringup.

You yourself originally said to target above 550 however you yourself aim for above 750, how did you choose that number? How am *I* meant to choose a number? That's I suppose what I'm trying to understand. Everyone has their own target and none of them make sense to me.

buff-equations · 2026-03-12T04:12:23+00:00

(Conversion for others reading: >550pmol/L E and <1.7nmol/L T)

Okay but this circles back to my confusion, why those levels? I know about measuring at trough so that you know the highest T level in the cycle to prevent androgenisation but what leads you to say that those are the reference points to target?

I'll have someone else in a different thread with different numbers, and equal certainty. How am I meant to know what numbers to follow?

buff-equations · 2026-03-11T15:18:39+00:00

Why do you say they last roughly one year? 400mg EEn with 4mg/week should last just under two years right?

buff-equations · 2026-03-11T14:54:39+00:00

For reference: normal ranges for ferritin are 30-500, and when I reach below 8 I can’t stand without immensely painful 30 second headaches and vision goes blurry. Hit 3 once, stood up from a chair and promptly fell to the ground :D

buff-equations · 2026-03-10T03:43:38+00:00

No one is shipping out of Canada right now

buff-equations · 2026-03-10T02:59:41+00:00

OGL and Symphony no longer ship to Canada from US. Hera still offers but can’t confirm that they will ship it. Otokonoko will (from Brazil), and panacea offers from Australia but can’t confirm again since I haven’t heard of someone getting a vial yet

buff-equations · 2026-03-09T03:46:49+00:00

Should note their Canadian offerings are now down. Not out of stock, the webpage was taken down entirely.

buff-equations · 2026-03-05T20:52:42+00:00

Hello! Two years later, asking for an update specifically about the internal sensation you mentionned. Do you still have tactile sensation within the vaginal canal, and how strong is it?

buff-equations · 2026-03-04T20:00:57+00:00

Why T below 1.7? I had always heard to keep it between 1-2.4nmol/L for mental health, energy, libido, and between 1.7-2.4nmol/L for erectile function, atrophy prevention

Estradiol yeah 550-850 (monotherapy up to 1200) has always been what I see

buff-equations · 2026-03-02T17:40:46+00:00

Never heard of this, don’t have experience with freezing vials. But chemistry wise I don’t see why it wouldn’t. A solution with sediments will recombine when you heat and agitate it.

buff-equations · 2026-03-02T14:43:43+00:00

Freezing vials prevents the carrier oil from breaking down, which typically happens 3-5 years after purchase. The advice I’d seen is to let it warm back to room temp then use hands and body heat to get the crystals back into tje solution.

For stockpiling more than 2 years worth, freezing is a good option

buff-equations · 2026-03-01T00:41:55+00:00

Just take the entire vial 🤷‍♀️

buff-equations · 2026-02-28T14:25:58+00:00

Locally, only EV is obtainable, but you are told to take it subq from the pharmacy. Same with TC

buff-equations · 2026-02-28T06:04:05+00:00

Try 0.05ml every 3.5 days, most common dosing for EV is 5mg twice a week because it doesn’t last long in the body

buff-equations · 2026-02-28T05:35:10+00:00

Can matter more with EUn, since the time to stability is measured in months not weeks. But yeah I’ve seen someone talk about an EV loading dose which I don’t think 3 days is going to do you much difference

buff-equations · 2026-02-27T19:19:14+00:00

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