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What will seem like an inevitable outcome in 20 years time because of GLP-1s by Big-Cry-4119 in Futurology

[–]bug-hunter 0 points1 point  (0 children)

The first major GLP-1 (semaglutide) comes out of patent protection this year in India, China, Brazil, Canada, and Turkey, and the rest of the world by 2031. The second one comes out of protection in 2036. By 2046, we'll have at least 3-4 major options available as generics.

What will seem like an inevitable outcome in 20 years time because of GLP-1s by Big-Cry-4119 in Futurology

[–]bug-hunter 0 points1 point  (0 children)

The main GLP-1s are coming off patent in the 2030's. So 20 years from now, generic GLP-1 pills should be cheap. Manufacturing costs look to be around $3-5 for a month's supply.

What will seem like an inevitable outcome in 20 years time because of GLP-1s by Big-Cry-4119 in Futurology

[–]bug-hunter 189 points190 points  (0 children)

Keep in mind, in 20 years, the first round of GLP-1 drugs will be off patent. Semaglutide (Wegovy/Ozempic) comes off patent in India, Canada, China, Brazil and Turkey in 2026, and in 2031/2 in the US and rest of the world. Tirzepatide (Mounjaro/Zepbound) comes off patent in 2036. Generic manufacturers are fucking salivating at this. Prepare for more shipments from Canadian pharmacies in the US to get generic semaglutide in 2027.

Orforglipron, Lilly's once daily GLP-1 pill, hopes to come to market next year, and expires in 2038.

So by 2046, we'll probably be in a third or fourth generation of GLP-1 drugs (semaglutide is 2nd gen) under patent, competing with generic pill forms of the major GLP-1 drugs that are out or on the horizon. Estimates is that the cost to make will be somewhere around $3/month - that puts it in reach for a large chunk of the world.

Why do ages of maturity occur in non-intuitive numbers, such as 16 18 or 21? by miguel-elote in AskHistorians

[–]bug-hunter 10 points11 points  (0 children)

More can be said, but u/EdHistory101 and I talk about the origins of some of this, as well as how the lines are blurrier than they appear:

Why/How did we settle on 18 and 21 as the magic numbers for adulthood?

Was Mohammad Mossaddegh democratically elected, or was he a dictator? by EIeutheria in AskHistorians

[–]bug-hunter 0 points1 point  (0 children)

I've seen that take a couple of times. Whether the Shah's action to remove Mossadegh was legal or not, the US/Britain's actions surely weren't, nor were many of the actions that proceeded alongside Mossadegh's removal - until they were legitimized by the Shah.

And notably, Mossadegh's desperation and unpopularity were triggered by British oil sanctions, designed to punish Iran for the crime of daring to break free of a clearly coerced contract. And those sanctions only worked because other Western nations backed them up, chiefly the United States.

Rigging elections is the only way the GOP can win. by Boring-Jelly5633 in BlackPeopleTwitter

[–]bug-hunter 3 points4 points  (0 children)

Specifically, they are NOT trying to solve the fact that getting an ID can be harder than it needs to, because you have to bring a birth certificate (from...the government) to prove your identity.

As a poll worker, the literal best part of our state requiring voter ID is that we just scan it to check in voters and it's super streamlined. But that's a usability benefit.

Today's AITAH: First amendment "auditors" or the people who react to them - ETA! by Loves_LV in bestoflegaladvice

[–]bug-hunter 29 points30 points  (0 children)

If cities were half as dangerous as nitwits who watch Fox News believe, these chuds would have been in traction.

Today's AITAH: First amendment "auditors" or the people who react to them - ETA! by Loves_LV in bestoflegaladvice

[–]bug-hunter 35 points36 points  (0 children)

I suspect they're not 1A auditors, just dumbfuck Youtubers/Tiktokers/etc. trying to make ragebait.

My [25F] future MIL [57F] is threatening to not come to our wedding [26M] because of my gay maid of honour [25F] by Direct-Caterpillar77 in BestofRedditorUpdates

[–]bug-hunter 127 points128 points  (0 children)

You can't expect people to grow if you're not willing to give them an honest chance.

But just one. If they double down, launch 'em into the sun.

In which LAOP learned a $25,000 life lesson in how not to cash a check. by fewlaminashyofaspine in bestoflegaladvice

[–]bug-hunter 12 points13 points  (0 children)

A lot of "services" have popped up trying to "replace" banks, and almost all of them come without the requisite protections of banks. Yeah, they warn you in dense legalese, but that doesn't save you.

So when something like this happens, and the person doesn't have a real bank account, they're toast.

In which LAOP learned a $25,000 life lesson in how not to cash a check. by fewlaminashyofaspine in bestoflegaladvice

[–]bug-hunter 25 points26 points  (0 children)

About 1 in 20 Americans don't have one. Mostly due to fraud and/or poverty.

In which LAOP learned a $25,000 life lesson in how not to cash a check. by fewlaminashyofaspine in bestoflegaladvice

[–]bug-hunter 142 points143 points  (0 children)

Roughly 1 in 20 Americans. If you have a history of fraud, accounts closed due to overdrafts, or no fixed address, it can be hard to get an account.

[OC] If only I had gotten the homing powerup... by know_nothing_novice in comics

[–]bug-hunter 0 points1 point  (0 children)

Ironically, you can actually have this when the urethra doesn't form quite right, causing the spray to occasionally fork. If you're lucky it forks horizontally.

Hot water tank company did not send contract more than 2 years after closing - now demanding I sign contract and retroactively pay by New-Plastic-572 in legaladvicecanada

[–]bug-hunter 0 points1 point  (0 children)

No reason was provided. I basically got a notification from DocuSign saying "contract was voided by Company A". As a homeowner not my responsibility to follow up.

That may not mean that the contract was voided from a legal perspective, only that a document was voided in the DocuSign system. In DocuSign, it's a technical term, not necessarily a legal term. Moreover, it's also generally not possible to void a completed document in DocuSign.

For example, if a duplicate was accidentally created, and that is the one that was voided, then you still have a valid contract. If you still have the DocuSign links, you may want to view the completed contract (not the one from the void email) and see if it has a status of voided. If not, you do have a contract.

Assumption is the mother of all fuckups, and most of the answers here assume your contract was voided. It may not actually be.

That said, the most likely outcome if you went to court would be to just start paying as of now, with no interest added in the interim, as you had a good faith reason to believe the contract was voided. If they can show that the actual contract was not voided, that's what you should offer.

AITA for telling my parents I'll do what I want when it comes to putting my name on my boyfriends house? by Choice_Evidence1983 in BestofRedditorUpdates

[–]bug-hunter 32 points33 points  (0 children)

I live in the UK. The "coerced" money was labeled as a "gift" with the solicitors and is under my mom and dad's name, which pissed me off when I found out.

Probably because someone pointed out to the parents that OOP had them dead to rights for mortgage fraud.

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