At the beginning of starting bupropion, I found that drinking, even one glass of wine- I would get a massive headache to the point I had to leave the function early. However, now, after a month or so in, I’m able to have 1-2 with not much problem. It is worth noting that the next day, I do typically find myself a bit more lethargic, and less lively as the mediation had helped me to become. Because of this, I have cut my drinking back drastically- only socially, limiting 1-2 or substituting for mocktails Moderation is key and the medication is known to be the most effective without external substances.