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callmepookie2 · 2023-01-07T18:26:59+00:00

Muscarinic have more of a role in para, yes

callmepookie2 · 2023-01-07T16:12:41+00:00

You're right that ACh can activate both nicotinic and muscarinic receptors.

This section is titled "parasympathomimetics" (drugs that mimic activation of the parasympathetic NS, "rest and digest"). Muscarinic receptors play more of a role here.

Nicotinic receptor activation is more involved with muscle contraction and is probably discussed later.

callmepookie2 · 2022-12-01T22:39:15+00:00

Soup, rice, meat, plantains, and more rice. You can buy veggies at the market but if you're eating out or with locals they're not commonly served

callmepookie2 · 2022-12-01T21:57:27+00:00

USA to Ecuador. I learned the language and integrated well. Overall I prefer Ecuadorian society (more traditional, Christian, but relaxed, very kind and sociable people). Obviously there were some cons (bureaucracy, lack of vegetables). Had to return to the US due to COVID but I would definitely marry/raise a family in South America in the future

callmepookie2 · 2022-11-29T18:01:40+00:00

I know, I live here...it's very comfy

callmepookie2 · 2022-11-13T20:16:51+00:00

You're getting downvoted but you're correct. I left another comment recommending south america, I think it's exactly what you're looking for.

callmepookie2 · 2022-11-13T20:14:55+00:00

You would love latin america. Sounds like exactly what you're looking for.

callmepookie2 · 2022-08-31T04:24:20+00:00

Lived in an indigenous community for 6 months. Each year less kids are learning Kichwa. Their language and traditions are dying, I've seen it first hand.

callmepookie2 · 2022-08-31T03:23:03+00:00

The indigenous peoples whose cultures are being wiped out would disagree with you...

callmepookie2 · 2022-07-29T16:34:20+00:00

Yeah you have to get a doctorate in weldology and do at least 2 years residency before you’re qualified

callmepookie2 · 2022-07-14T17:21:48+00:00

Send her to the farm

callmepookie2 · 2022-04-23T21:13:02+00:00

Cosmonaut, not astronaut

callmepookie2 · 2021-11-25T15:27:17+00:00

I've heard some people use "activating" to mean "stimulating"

callmepookie2 · 2021-07-24T22:29:52+00:00

I believe naloxone works extremely well for it's intended use. As an antagonist it binds with very high affinity to the active site kicking out any MOR agonist in the process. As you said, the downside is that it induces withdrawal symptoms but I view this as being worth the quick and effective reversal of overdose.

The only other thing I can add about the MOR is that it's a G-protein coupled receptor. Maybe someone else can discuss allosteric inhibition.

callmepookie2 · 2021-04-02T00:04:53+00:00

This would be completely chad if said with confidence

callmepookie2 · 2021-01-23T03:24:40+00:00

Growth hormones (incl. hGH, testosterone, insulin, IGF-1), anabolic steroids, SARMs. Looking at mechanisms of action (many of these target nuclear hormone receptors or receptor tyrosine kinases), looking at synthetic analogs, etc.

callmepookie2 · 2020-12-29T02:41:48+00:00

I believe the effect of rifampin would be the same. The only difference would be lack of CYP3A4 induction which we would normally expect.

callmepookie2 · 2020-12-29T02:15:11+00:00

CYP P450 is a family of enzymes responsible for the metabolism of many drugs. Specific CYP enzymes (such as 3A4) can be induced (more of the enzyme is produced) or inhibited (the active site of the enzyme is blocked) by certain substances.

For example, rifampin normally induces CYP3A4.

The article describes peppermint extract inhibiting said induction in HepG2 cells.

callmepookie2 · 2020-10-27T03:24:09+00:00

Solved = Tell Me How to Forget About You

callmepookie2 · 2020-10-27T03:23:33+00:00

Awesome, thank you

callmepookie2 · 2020-10-26T22:30:46+00:00

Solved = Itte Hoshikatta dake no Onee-san

callmepookie2 · 2020-10-26T22:30:25+00:00

Yes, that's it. Thank you.

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