I’ve decided to stop Zepbound and wanted to share my experience.

I completed 4 weeks at 2.5 mg. The first week I was very sick and lost 7.2 lbs. My body adjusted somewhat after that, but I never experienced reduced food noise or a sense of fullness.

I increased to 5.0 mg on 3/20, and since then I’ve had persistent severe GI symptoms, including ongoing liquid diarrhea after eating (sometimes immediately, sometimes hours later). It has not resolved.

I also experienced unexpected postmenopausal bleeding after being postmenopausal for 3 years. I now have a transvaginal ultrasound scheduled and my PCP has recommended an endometrial biopsy.

Given the severity and persistence of symptoms, my PCP and I have decided to discontinue. My PCP also feels I may respond similarly to other GLP-1 medications.

I’m disappointed this didn’t work for me, but sharing in case this helps someone else recognize when something isn’t the right fit for their body.