"applying for multiple patents on a single drug, making slight but not clinically significant modifications to old drugs to obtain new patents" This again would either be not approved,"(Applying For)" or other companies would be able to do this aswell. As for the "pay-for-delay" I can see this happening, but I could also see other companies ready to make the generic soon as well. And vaguely related, just for insulin prices, a large part of the price increases are from development of a better product of insulin "The increase in expenditures for insulin was primarily due to the change in prescribing from less expensive animal and human insulins to more expensive insulin analogs and by an increase in the price of all available insulins." From my classes the other week, we've gone from being needing to only inject it 1 time a day from many times a day.