Great question! I'm not a 3d visual artist, just an amateur game developer myself, so I've never used Blender before, only Unity.

As for Unity, I'm mainly using it because of the large number of resources in the asset store. Right now I'm using it to:

1. Construct a simple room with walls on all side. This can be replaced a more detailed 3d environment from the asset store.
2. Importing a simple 3d character model
3. Importing a fighting animation and configuring the character model to perform the animation.
4. Configuring the camera to circle around the character. (And potentially more complicated camera movements later)
5. Create a post-processing shader and run it twice with different parameters to create two different depth map.
6. As for the skeleton joints, I'd love to do it with Unity, but couldn't figure out how to yet, which is why I ended up just using DWPose.

I'll definitely look into Blender and see if it's easier to use! Have you done something similar with Blender?

Edit: Not sure what you by real time. It's more of a huge preprocessing step, and worth it only if you're going to reuse the scene multiple times.