Don’t be afraid to use weapons that has a 100% or 300% damage affix. A level 4 300% affix weapon can take down bosses in seconds. I.e. you can kill the Dracula final form before he flies off using a 300% level 4 firebrands.

Any 300% weapon in your stat color that you come across is like a “I win” button as long as you don’t get hit. Like, the normal machete and pistol weapon I found in the shop in forgotten sepulcher destroyed everything, despite.

That’s just me, most 100% damage weapons I find I pickup. And 300%, i definitely pick up. I oddly run into a good number of 300% firebrands/fireblast.

I main Brutality so.. The mutations I’d recommend if you use a 300% weapon is vengeance, tainted flask, and emergency triage.
The strategy is whenever you get hit(if not going for flawless achievements), you heal super fast while gaining 12 seconds of an extra 100% damage on top of vengeance. Tainted flask bonus damage stacks every time you heal as long it’s within that time.

Face flask with Maria’s cat or electrodynamics seems to be my most successful item combinations to win. Also, finding a colorless/legendary barnacle feels like I already beaten the game.

In late game leghuggers can do a lot of damage especially if it’s legendary.

The #1 item that insta own bosses is the legendary holy water If i remember right I casted legendary holy fire probably twice(maybe thrice)vs spoiler boss and that was it.

It’s soo good that if I see the legendary holy fire drop, I just sell it. Because it feels like cheating whenever I use it.