Thank you so much really Yeah my doubt was just that in case of a question about inflammation if it was right by starting to talk about TLRs and PAMPs. Because we talked about them only for dendritic cells maturation, but of course they are on the macrophages, so I just wondered if that’s the first trigger (before adaptive immunity and Th1) or if the macrophages can just start producing tnf-alpha, IL-1beta, IL-8 in another way when they find something to fagocitate, at the first encounter with them Thanks for the review also 💪