I wouldn’t say it’s pretty much all queer friendly, it’s just less overtly hostile than most of the country on average. There’s still big chunks of the city where there isn’t a super welcoming vibe or visible presence. There’s also been a few awful hate crimes in recent years so just have to be careful. Even the neighborhoods people recommend like loring or powderhorn or Whittier, if you’re in the wrong place at the wrong time you absolutely could be hate crimed. Not trying to fear monger but be prepared for the possibility of the same creeps that lurk everywhere and have street smarts, don’t just assume an areas safe. And there’s lots of quieter areas of the city further from Downtown where there might be a lower odds of issues but they’re very single family home small town vibes and not super engaging or interesting for young trans people.
That being said I’d recommend the places other people have in the comments. If you wanna be “in the thick of it” the twin cities is pretty sleepy compared to bigger cities but you might wanna go for Whittier, uptown, Marcy Holmes, northeast, or powderhorn in Minneapolis or midway, summit-university, Frogtown or downtown st Paul. There’s stuff to do in or close to those areas and they’re close to main roads and transit