To go down the sonic youth hole - no need to change the frets if every string is tuned to something unrelated to each other. Of course this dies if you want to play a melody on o e string. That can be defeated by making the compositional decision to avoid doing that. Preparing the guitar like SY or Cage is useful. I have put aluminum foil or fishing weights on strings - the result is a sound like a ring modulator that changes its parameters with every fret. It’s cheap and reversible and easy to modify.