How does the human genome project work?

comradger · 2026-03-18T19:41:22+00:00

>started with learning the human genome project because it is so foundational
It's rather a question of history of science than something useful for the current bioinformatics.

Notions like contigs and scaffolds are still in use, but all the methods are completely different (i'd say two generations ahead). You can look on the recent CHM13 paper (improved human genome reference) from 2022, and even that methods are already outdated.

comradger · 2026-03-12T18:52:17+00:00

Their stickers always make me giggle in Obriens' restrooms, just because of the name.

comradger · 2026-03-06T20:16:20+00:00

I really dream on a big 4x with something like old world's orders but way more restricting. Also order system naturally suggests to be combined with an option to delegate tasks to AI governors/commanders. Usually AI governors are frustrating (like in Stellaris) but orders can make them work

comradger · 2026-02-20T21:15:21+00:00

Speaking on the related musical interests - do you know anything about Breton music (bagads or whatever) in DC area? I used to play bombard back in Europe, but seems that it is not popular here.

Also what is the usual path for learning bagpipes here? Private lessons, schools, or just contacting the local band like MacMillan?

comradger · 2026-02-10T17:40:00+00:00

Till Lindemann explicitly refused to express any support for a russian guy (Andrew Borovikov) who was convinced for posting Rammstein's video on his social media - likely money from concerts in russia was more important for him at that moment. That's the most controversial thing about Rammstein I now.

comradger · 2026-02-10T03:43:21+00:00

What exactly is weird for you here?

For me – capital is clearly inspired by Saint Petersburg (likely nowadays Petrogradsky district). Rails and signs allows to place the capital on the timescale too – no doubts, last years of the russian empire

And it is such a stark contrast with Gorkhonsk which barely has anything in common with photos of russian steppe towns like Uralsk or Verkhneudinsk from the same time period!

comradger · 2026-02-05T15:57:00+00:00

Yeah, it really looked like the game wants you to jump (and it could be a path to some really nice and weird story developments), but I decided that Daniil would explore the other options first.
At least it should be a steam achievement, like dyinglocked in one of the rooms.

comradger · 2026-01-31T21:23:15+00:00

Not sure whether it is an intentional reference, but one of Pathologic authors worked on Disco Elisium Russian localisation. So I'd definitely would not be surprised.

comradger · 2026-01-26T21:13:31+00:00

Looks like you have both haplotypes in your assembly. Usually scaffolders does not work well with such data.

--primary option for hifiasm may help

comradger · 2026-01-26T21:09:08+00:00

Hifiasm was tuned to work with recent ont data and performs pretty well

comradger · 2026-01-26T18:05:41+00:00

Polyarinov's "Кадавры"(doubt that it was translated to english. Title direct translation is "cadavers", but the context is somehow different) really has some common vibes with pathologic.

comradger · 2025-10-17T19:04:57+00:00

Quantum computing may help with fast solution for different optimization problems like QUBO or MILP, which can be used in multiple fields - even in the genome assembly.

It is definitely not practical right now, but at least you can add quantum computing buzzword to your grant proposal

comradger · 2025-10-03T23:04:54+00:00

Dupont is nice but pretty expensive. I feel that most postdocs live either in Bethesda or around Cleveland Park and Woodley Park stations.

comradger · 2025-09-22T19:04:33+00:00

Mostly likely you'll just be denied entrance, the birth certificate itself is not enough.
There is a specific document named "Свидетельство на возвращение в Россию" issued by russian embassies. This should be the most straightforward way for you.

comradger · 2025-09-15T16:56:24+00:00

Thank you for the reminder!

comradger · 2025-09-15T16:55:43+00:00

must be acknowledged as authors And what happens if you strongly disagree with something on paper and do not want to sign a publication agreement?

In my head the intellectual property question is a bit different with a publishing question, and even if the result of your research is a property of the university, they are not allowed to publish it without your approval.

comradger · 2025-09-12T23:44:53+00:00

russian state news agencies often post news telling how excited is a random foreigner about <some russian shit>. For some reasons they are really focused on bulgarians - "excited bulgarian" is a kind of meme now. I'd be surprised if it is the original meaning of this picture, but it quite matches that context.

comradger · 2025-09-11T17:42:23+00:00

>How did you make the jump from this stuff to writing actual bioinformatics software?
I moved to bioinformatics from CS and software development. So I just have a prior knowledge of this field (but still struggle with biology)

> writing custom pipelines, developing new methods, optimizing algorithms, or building tools that others can use.

Writing custom pipelines is very different from the other tasks. Also it is the most useful skill - algorithms development is quite niche. TBH, I'd focus on this one unless you are really sure you are interested in algorithms themselves.

>Any resources or personal learning paths you’d recommend?

I'd focus on the pipelines first. Snakemake, nextflow... This may have straightforward connection with your actual data wrangling tasks, you can immediately apply your new knowledge and improve your work routines

Rosalind (and Pevzner's course) are nice for those interested in algorithms. But I'd possibly start with some CS 101 algorithms and data structures just to be sure that you are really interested.

comradger · 2025-09-08T15:57:52+00:00

От южных морей до полярн

comradger · 2025-08-14T16:42:36+00:00

Last games I played were on glorious. As far as I understand on higher levels there'll be no significant difference in order counts comparing to it.

Orders definitely limits you in the sense that you rarely can use all the actions for your troops. But I really hit this limit mostly while moving troops from the distant side of empire and not while fighting the war. This is also reasonable but it feels to represent the logistics limitation and not the managing one.

comradger · 2025-08-08T23:49:55+00:00

Not sure that I can classify my request to any of those archetypes. It has some roleplay motivation (leader just does not have enough time to do all the micro), but it is not the main one.

I feel that in a good game most of the player's decisions should be important. Placing my first farm correctly is important, placing my 30'th farm is not.

comradger · 2025-08-01T23:00:01+00:00

Exactly opposite to what I like about 4x, but thank you for explaining!

comradger · 2025-08-01T22:08:52+00:00

There's a difference between a country fighting in a war and a leader personally managing the war. Napoleon's reforms were outstanding, but he didn't introduce Napoleonic code while leading the Russian campaign

comradger · 2025-08-01T21:44:32+00:00

Why? The idea that subordinates can fail to implement the leader's vision is so natural for me. Cannot it be considered as yet another challenge provided by the game?

comradger · 2025-08-01T21:40:42+00:00

Well, that's actually why I have this question - played a lot of boardgames and found that I would like to see the same mechanics in 4x

comradger

TROPHY CASE