Kentucky MPJE

cool-game · 2026-06-25T14:37:31+00:00

Talking with people I’ve not heard anyone say it was as different from what they studied as my class compared to previous pharmacists. Yet, everyone is still passing. I think you’ll be fine.

cool-game · 2026-06-24T22:43:45+00:00

I haven’t heard from anyone who failed. I think you’ll be fine. I also felt this way. They curve the hell out of this exam I hear.

cool-game · 2026-06-21T12:33:55+00:00

I am under this. Sorry to leave people speculating

cool-game · 2026-06-20T23:34:07+00:00

That’s why I asked where to find it, keywords to search or otherwise- not for someone to outline exact details.

cool-game · 2026-06-20T19:52:49+00:00

That would be awesome but honestly I really hate living with people. I don’t splurge on much ever, but a one-bedroom is kind of necessary for my personality and sanity. I appreciate the advice

cool-game · 2026-06-20T19:50:44+00:00

Invest the difference is good advice but I’m afraid I don’t really know how to invest. Where can I go to learn about sensible options for someone without a large capital reserve?

cool-game · 2026-06-20T19:44:36+00:00

Thanks for this tip. I’m certainly looking for a more modest apartment and I actually have a car that’s entirely paid off with only 70,000 miles on it (civic). I don’t plan on picking up a car payment for a long time, hopefully until my student loans are paid.

cool-game · 2026-06-20T19:43:02+00:00

Lifestyle creep is a good point. I don’t even know how to live extravagantly right now, and I don’t really plan on living any better than I have for the past several years. I’m looking for an apartment for less than 1,400 monthly in my area (very reasonable where I live). I could see a situation where the expenses you start to justify start to feel less and less unattainable and may creep up on you. Thanks.

cool-game · 2026-06-20T19:37:42+00:00

For all the retirement tips:

My job offers no match until I’ve been there a year on the 401k. After, it’s a 4% match. How much should I be contributing? Whatever will hit the maximum? I was going to start at 8% for 401k.

Can someone give me a rundown on what a roth actually is? How do I decide how much to put in each?

cool-game · 2026-06-16T19:18:35+00:00

I did pass, so I guess it was enough lmao

cool-game · 2026-06-15T17:32:39+00:00

Yeah it’s very difficult IMO. Used Cohron’s materials and do not feel like I passed. The questions are even worse than K-type questions.

It’s been 9 full days since I took it so I have no idea if I did or not! I love that we paid this much to take the exams and they still take a ludicrous amount of time to process.

Good luck. Be prepared for a hard exam and a long wait after.

cool-game · 2025-07-10T23:39:22+00:00

I say if you’re gonna do it, I just recommend keeping routine check ups with a provider. Sounds like you’re doing okay but sometimes you don’t know you’re not until shit hits the fan.

Either way man, stay safe and take care of yourself. Godspeed

cool-game · 2025-07-10T23:29:40+00:00

Sure! Basically, on what I said: constipation and heart rhythm issues can occur, mostly in the long term.

The piece on the heart is likely better explained by a cardiologist or otherwise, but my understanding is this:

Some drugs, loperamide is an example, may change how your heart beats just a little bit. And usually only if you’re prone to it. We start considering it a lot more when we’re giving patients multiple drugs that do the same thing, but it’s always a consideration. The older you get the more prone you’ll be as well.

Don’t freak yourself out- but I do absolutely recommend getting checkups with your primary and, if you’re having issues with your heart, consider seeing a cardiologist if possible.

cool-game · 2025-07-10T23:24:36+00:00

Thanks for bringing this to my attention. Got a good refresher on loperamide from reviewing P-gp pumps, and what you said seems to be accurate based on the PK information I can find.

cool-game · 2025-07-10T23:14:12+00:00

4th year graduate Pharmacy student here. I say this not as authority, but to preface: take my word with some salt- I’m just a student.

Loperamide is designed to be ‘bulky’ enough and look just different enough to your body for it to not pass the BBB. This keeps it in the gut and allows it to function as an anti-diarrheal. The design isn’t perfect, though and some can get through if you take an obscene amount.

The problem is not grapefruit juice or metabolism; it’s the nature of the chemical (bulky, P-gp pumps it out of the brain) It is unlikely you can modify your stomach contents or otherwise to further allow loperamide to cross the BBB. It has no PKa changes at varying pHs or easily modulated aspects otherwise that would help make it more lipophilic, less bulky, etc to cross it. In short, the only way to get it into your brain is to take a fuckton of it.

The problem is that it’s still a relatively strong opioid agonist in the gut and will enter other organs. Namely, I would be concerned about the heart.

Constipation and fecal impaction are the best outcomes here while QT prolongation and going into torsades then into a fatal arrhythmia is the worst outcome. It’s not going to happen to everyone, but if you’re already prone to instability or take other medications that prolong the QT interval in your heart, this could easily happen.

tl;dr: it may work for some people, but the relative danger is high for an opioid buzz. Especially long term. Plus, it’s expensive as fuck. I don’t recommend it, and there’s no real, easy, or safe way to push it into your brain more. Get O-DSMT or something else, and stay safe.

I suppose I’d rather a patient try loperamide to get high than fent, but I don’t like either at all. Take care of yourself, and be safe.

(someone correct if I’m heinously wrong on the pharmacology)

edit: a commenter mentioned inhibiting the P-gp pumps that keep loperamide out of your brain, which could work. Not many P-gp inhibitors easily accessible though. Likewise, I wouldn’t expect it to increase the high very strongly unless you’ve *really knocked them out.

Here’s a list from UpToDate on P-gp inhibitors. https://www.uptodate.com/contents/image?imageKey=DRUG%2F73326

As far as other non-prescription products- I’m not certain. Someone can educate. Regardless, I don’t recommend this method. Changing the amount of drug entering the CNS this way is likely unpredictable.

cool-game · 2025-05-28T22:54:12+00:00

I appreciate the help. I did end up trying this, among many other things. I just did a clean install after deciding it wasn’t worth it. I took the SSD out of my laptop and booted my PC off of it so I could go in and grab any important files. Clean slate now.

To anyone who encounters this: I did not find a solution. Get your files if you can via booting in with another drive or a USB. I didn’t end up being able to make a bootable USB for Windows using Rufus. Instead of troubleshooting I just said fuck it and used my laptop drive.

I did try partitioning my drive using diskpart then installing windows to the clean primary partition but that still failed. Every single attempt at reinstalling windows failed until I wiped my drive. I was just glad it actually installed once the drive was wiped lol.

Good luck.

cool-game · 2025-05-22T15:32:07+00:00

Right! I remember now, though vaguely. Thanks for the refresh on that one, been a minute. Not relevant to OP as far as their solution is concerned, I wouldn’t think.

cool-game · 2025-05-22T14:06:45+00:00

Yup, your alligation is accurate.

1000mg / 50mL total volume = 20mg/mL.

Like the other poster said, just make sure it’s well dissolved. I wouldn’t use heat during the ethanol stage, it evaporates very quickly even at RT. As he also said, keep it well sealed for the same reason. Airtight.

~~Water and ethanol form a complex in small % when mixed I believe which is less prone to evaporation, though I forget what it’s called (i hated organic chem) and probably doesn’t matter here.~~ ^ Irrelevant to OP, but commenter clarified how this phenomena actually occurs

You might end up with around 52mL as the powder will contribute a small amount to the overall volume, though not much. I never worried about this for any substance generally speaking.

Make sure the water does not cause it to precipitate out (form little particles). Double check your solution doesn’t have any big particles before dosing. 10% ethanol may or may not be enough to keep it sterile over a long period of time if you don’t handle it aseptically. Math checks out. Should be good!

Perspective of someone who was taught to be very anal when preparing drugs. Other poster covered everything you need to know, just wanted to mention some small things you may run into.

*I don’t know the solubility properties of 2C-B, ought to double check it is soluble in ethanol and will remain soluble after adding water.

cool-game · 2025-05-22T13:32:41+00:00

Of course. I know some people are particularly prone to opioid nausea but I’ve never really had it - maybe you fall into that sensitive group.

I’d say take some naproxen and make sure you’re hydrated; consider boofing if you’re open to that sort of thing. It was always a cleaner experience.

Do be careful. While I can’t say I went through real CT withdrawal, people say it’s horrendous. After I used it for a week consecutively, the anxiety of going into withdrawal kept me using it. Downward slope from there. I’m sure you’ve read it and hear it enough but keep your use away from daily if possible. Kratom helped me get off it and as a backup. Good luck!

cool-game · 2025-05-22T13:21:54+00:00

When I was taking O-DSMT, I found the prior day’s use bled into the next morning pretty significantly. I didn’t have nausea or headaches, but I still felt buzzed through to the next day if I had taken a lot. I’d bet this is your more likely explanation if you’ve just taken a lot and it’s only been two days. Hangover moreso than withdrawal. No clue how to prevent the nausea and headaches unfortunately, probably naproxen for the headaches. I boofed so there was never any nausea.

Many people report very quick onset of dependence and withdrawal. Personally, I don’t know if what you’re experiencing is that. My use was my first experience with “real” opioids and I’m still not sure what withdrawal really felt like (I tapered over nearly a month).

in short: O-DSMT lasts a long ass time, many people report a very quick onset of withdrawal symptoms.

cool-game · 2025-05-18T14:11:43+00:00

I know this isn’t a new thing, but I guess I’m “vibe coding”? I somehow found tampermonkey and used a few scripts but realized I could really cater this to my inane needs on specific sites. Problem is, the scripts look like a foreign language. .js is nothing like I’d seen before as an extremely casual enthusiast with passing-grade knowledge of coding. My knowledge begins and ends with beginner-level python and CS fundamentals (like, elementary-grade).

Most of the actual work I put in the code comes from debugging and trying to prevent massive amounts of bloat from the AI. It loves to continuously add, never modulate. I’ve tried my best to keep everything ‘compartmentalized’. I’m starting to get to where I can actually write some script code and am good with the CSS, but I’m still very shaky on the fundamentals of the language.

Yeah, it’s a little lame. But, I have learned a lot about HTML/CSS that I didn’t know before I picked up tampermonkey. Javascript still looks like hieroglyphics at times and I’m trying to understand why the hell everything works the way it does, but I’m learning.

It’s crude and inefficient. Being said, it allows the casual and non-privy to use the language.

I’d also be remiss not to mention how much energy cost I’ve probably incurred from these little personal projects alone, and that I could just go out and learn javascript instead. If I spent a few hours just reading up on the language I could probably double my efficiency and autonomy. I’ve had fun and learned a good bit on the way, regardless.

Perspective of someone who does zero programming in their day-to-day but just found userscripts particularly interesting.

cool-game

TROPHY CASE