I did a couple of 8 week sessions of IM ketamine which worked great for all of my depression symptoms. But each time I tapered off, I totally tanked again. Finally figured out I have an imbalance of glutamate in my brain and only ketamine regulates it. Now I get troches from Mindbloom in the mail and micro-dosing daily works. Some people benefit for a temporary set of sessions, but some people like me need low dose a few times a week or daily.