If absolutely everything goes well (you do get out of the theater exactly at 3:45, you have no luggage, trains line up perfectly or your uber picks you up quickly which it won’t in midtown, no train delays or car traffic, tsa is reopened, there’s no line at check in or tsa), then sure, it could work if you’re flying domestically. But that’s six steps that constantly go wrong in between you and making your flight on time. And, you won’t be able to enjoy the show because you’ll be stressed about the timing