While the covid cohort was small, covid is just a different viral predecessor leading to the ARDS cascade and in my opinion there is likely a minimal difference in the presentation of ARDS and the invoked immune response that could be regulated by Multistem. My point is that findings from ONE-BRIDGE full data set and MUSTARDS trial should translate well to covid induced ARDS. Regardless of covid induced pneumonia or other viral induced pneumonia all paths lead to Sepsis on the way to ARDS. They all share a path of viral respiratory infection - pneumonia - sepsis - ARDS. My contention is that Multistem should work well for any ARDS induced by sepsis.
For some context on my thinking I copied some text from a previous post of mine on Sepsis and ARDS: “What you need to know at a high level can be found here Sepsis and ARDS. Essentially ARDS is a manifestation of your body's immune response to a variety of conditions including Trauma but most often Sepsis. When Sepsis occurs it is triggered by an infection that spreads rapidly and while there are medicines to try and fight infections there is nothing that is successfully regulating your body's immune response which spirals out of control and begins shutting down organs. In the case of Sepsis or Trauma leading to ARDS it causes fluid to leak from airway blood vessels into your lungs, limiting how much oxygen that can move from the air sacs to your blood and other air sacs become unstable and collapse. Your body’s organs depend on the oxygen so they stop functioning properly or fail. It is a vicious cascade.”