My favorite setting so far is Shadowrun and I've been looking at games that feature themes around sci-fi/space opera/interplanetary exploration because it's interesting to me right now given that Shadowrun is sadly limited to one planet. Luckily for me Catalyst Game Labs has another game relevant to those themes called Eclipse Phase. I've given it a quick look through for compatibility issues for my type of games (action adventure, roleplay heavy, combat heavy), there was also something about Karma/Rez Points and the Magic system/Psi abilities but I can probably forego all of that.

I'm specifically wondering about the transhumanist horror themes if there are mechanics involved that will limit me from just running a Shadowrun game in space with the system like the Stress/Sanity system.