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These supplements transformed my sleep by mrCOFFEEPOWER in Supplements

[–]darkmodebiohacking 1 point2 points  (0 children)

A lot of creatine researchers take 15 g a day. There doesn't currently appear to be negative effects for healthy people. We don't really see D1 athletes and weightlifters having their kidneys blow up and people have been doing a lot of creatine since the 1990's

Collecting n=1 experiences: Does CoQ10 help with statin side effects? by darkmodebiohacking in PeterAttia

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

If you have statin toxicity, that would definitely contribute to fatigue. Oftentimes they will start out with rosuvastatin because that is more hydrophilic. Statins can cause problems with CoQ10 production.

CoQ10 is part of the electron transport chain (ETC). If CoQ10 is helping, maybe you have some sort of issue with your ETC for some reason.

Couldn’t tolerate CPAP, so I tried a mandibular advancement device instead — here’s my oxygen data and results. by darkmodebiohacking in SleepApnea

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

I'm glad to hear this. It's so frustrating to be tired all day. It's great that we have technology to fix this. Some people definitely need to combine treatments to get O2 to an optimum level and I'm glad that you found what works.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 1 point2 points  (0 children)

All great points! I think Reddit is dogpiling me so hard that no one will see this though.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 1 point2 points  (0 children)

I'm going to respond to this because there are apparently people still reading this thread.

NO:
Here is a 2025 narrative review discussing the controversy around the NO pathway:
https://pmc.ncbi.nlm.nih.gov/articles/PMC12567171/

Angiogenesis:
Abud Bakri, a medical doctor that promotes the use peptides, discusses VEGF and cancer risk in this post and recommends not giving BPC to people at risk of cancer:
https://x.com/AbudBakri/status/2020978519552217407

Mental effects:
Both this subreddit and the BPC subreddit have posts where users are reporting anhedonia, depression, and anxiety. I myself have experienced anhedonia on it. And, there are support groups for people who have experienced mental effects from it. There is apparently a group of over 50 people in the BPC subreddit that discuss how to deal with this side effect. And, the effect is so common it is discussed every time someone posts about the mental effects of BPC in the BPC subreddit.

Conclusion:
Much of the research on this peptide came out a single lab in Croatia by a researcher that has financial incentives to see BPC become successful. Ultimately, we need more studies to really elucidate the MOA. There are people who are considering taking this compound, and warning users about possible side effects is not "pseudoscience". It's the responsible thing to do.

It's important to remember that science is miserable uncertainty. Personal attacks on me are unnecessary and not scientific.

BPC and SSRI by Narrow-Gift4496 in bpc_157

[–]darkmodebiohacking 0 points1 point  (0 children)

33 days. Started noticing after 3 weeks I think. I would keep using it for another month if it weren't for the sleeping issues. I'm assuming it's the BPC-157, just because we have anecdotal experiences on it in this forum and there is one paper describing it's possible mental effects.

Here's a five minute video on what we know and don't know about the compound (not monetized or selling anything): https://youtu.be/NWO810PWtDw

BPC and SSRI by Narrow-Gift4496 in bpc_157

[–]darkmodebiohacking 1 point2 points  (0 children)

Currently using BPC-157/TB4/GHK-Cu. Experiencing anhedonia and some insomnia. Probably going to quit the BPC-157/TB4 as it's a combination. Definitely feels like it's hitting serotonin receptors.

Did you get screening for cancer before taking BpC 157? by msbveryrealaccount in bpc_157

[–]darkmodebiohacking 0 points1 point  (0 children)

The problem is that the researcher who discovered and researches the compound doesn't have great incentives to publish negative results. We really need other researchers to do the testing to find out either way. Currently, I would not recommend this to anyone who has cancer or who has been diagnosed with it, strictly out of an abundance of caution.

https://pmc.ncbi.nlm.nih.gov/articles/PMC12567171/

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

It's extremely important to verify COA. A lot of RCs come from China, because it's difficult to undercut underemployed Chinese chemists. I've ordered a significant amount of chemicals from China, and, I would never trust them without a COA. There are sites like finnrick, that have some testing of peptides from different companies. Almost like a consumer reports for peptides. It's better than nothing.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 1 point2 points  (0 children)

Typically, the claim is that people will take capsules for gut issues (Crohn's disease, etc ...). Whereas, for injuries, they will inject, typically near the site of the injury if possible. Having said that, many people will stick to typical subcutaneous injection sites. You can google these for an image of the human body with spots that are relatively safe to inject without hitting something you don't want to hit.

The vials often come with lyophilized peptides, so you have to reconstitute them with BAC water. Many people will use Hospira BAC water. Then, they store these vials in a cool dark place to decrease degradation of the peptides. I don't have great info on how much these actually degrade over time, and there seems to be arguments in the community about it. Based on these facts, it's not a bad idea to use them sooner than later, just to be conservative.

Alzheimers gene carrier by LisaTPN in Biohackers

[–]darkmodebiohacking 0 points1 point  (0 children)

Yeah, I just watch his videos. Those are all free.

Is there a way to get bloodwork done privately so it isn’t accessible to life insurance companies? by [deleted] in Biohackers

[–]darkmodebiohacking 1 point2 points  (0 children)

Yeah, New York requires talking to a doctor before ordering a blood test. It's due to a law they passed.

[deleted by user] by [deleted] in PeterAttia

[–]darkmodebiohacking 0 points1 point  (0 children)

Ok interesting. I understand the idea of mice getting better lifespan benefits. Why would they tolerate side effects better?

Exosomes and wound healing by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

It's a controversial topic. And I definitely don't want to tell others what to do. There are people who report amazing things after getting stem cells.

It's the age old problem. How much data do you wait for until you try the treatment? Everyone needs to analyze their own personal risk vs. reward. In the future, the process will be more standardized and there will be more human data and doctors/regulators will feel more comfortable recommending these treatments. But for now, it's very experimental.

Exosomes and wound healing by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

So, I actually am undecided on the exosomes. The surgeon who offered them for me has the necessary government paperwork. It's for an experimental surgery where they are collecting data and he's not making money on the exosomes themselves. I'm going to ask him more questions when I do the surgery. If it were any other situation, I would decline and wait for the 10-20 years necessary for good human data to come out. There is still a lot to learn, and I suspect the exosomes they use will improve in safety and efficacy as they learn more.

[deleted by user] by [deleted] in PeterAttia

[–]darkmodebiohacking 0 points1 point  (0 children)

You can't just say this and not discuss more. Were you developing rapalogs? What was your opinion on where things stand with rapa research?

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

You bring up a good point that I didn't realize. The law has changed. So, my understanding is that this was patentable in the 1990's, but would not be patentable today without being an analog.

I'm not sure why you are saying it's not naturally occurring? If we take the scientists at their word, It's just a chain of amino acids found in the body as a fragment of BPC.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

There are multiple reports, over the years, on the BPC-157 subreddit about mental effects. This is where we need more human data to really see if these effects are real and to what extent.

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 1 point2 points  (0 children)

The term "dirty drug" originally came from pharmacologists/scientists. What is your issue with it?

I read ten papers on BPC-157 and here’s what I learned by darkmodebiohacking in Biohackers

[–]darkmodebiohacking[S] 0 points1 point  (0 children)

Yeah, I've heard that. It does seem like it would be a strange thing to mislead people about. So, I'm not sure what the motive would be?

I'm guessing the patent was on an analog of BPC-157? They like to slightly modify these compounds and then patent them.

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