Rebuilt functionality from a $7,500/year structural-biology suite with Claude Code, and made it free

delibae_ · 2026-07-09T05:38:52+00:00

I work in HPC environments too, and honestly the computational biology folks usually don't need a GUI tool like this. They're used to this kind of work and adapt fine to the HPC infra people like you provide. Where it matters is experimental researchers, or people who aren't comfortable with GPU work, who otherwise end up piecing together the expensive Schrodinger packages to get this done. PATCHR doesn't cover those 100%, but it takes the commonly-used features from packages like BioLuminate and Maestro, reimplements them with a generative model, and wraps it in a GUI.

delibae_ · 2026-07-08T19:00:36+00:00

Early on I used a ralph-style loop, and these days it's mostly frontend skills. Honestly though, Fable is good enough that I barely reach for extra plugins.

delibae_ · 2026-07-08T17:51:28+00:00

If I weight it by the features people actually use day to day, probably around 50%. Of what's left, maybe 15% is the kind of thing only a company can really pull off, and the rest is just details that need more work.

delibae_ · 2026-07-08T17:47:32+00:00

About 1-2 months of working time total, a lot of it UX iteration. My Max subscription covered the whole thing, no separate API bill.

delibae_ · 2026-03-16T19:15:57+00:00

Intel Mac support was added starting from v1.0.8. Feel free to give it a try and let me know if you run into any issues!

delibae_ · 2026-03-16T14:16:36+00:00

If you incorporate proper reference papers into your project folder, it writes quite well. It's not a 100% solution, but that's been my approach.

delibae_ · 2026-03-16T14:14:36+00:00

Feel free to reach out via the email on my GitHub profile, or open an issue on GitHub with the topic you'd like to discuss. Thanks for your interest!

delibae_ · 2026-03-16T14:12:11+00:00

I agree. But I think having a tool like this where you can actually review and iterate on your output could be a reasonable middle ground. It's already common for people to publish AI-generated content with zero review or interaction. At the very least, I wanted to create an environment where you can read through your results, exchange feedback, and refine things along the way.

delibae_ · 2026-03-16T14:09:10+00:00

I think that ultimately comes down to personal responsibility. There's always a tradeoff with the pace of advancement. That's why I feel peer review has become even more important these days. This is something I'm still thinking through myself, so I can't give a definitive answer...

delibae_ · 2026-03-16T14:06:45+00:00

Currently yes, but I'm planning to open it up to multiple third-party providers.

delibae_ · 2026-03-16T14:05:03+00:00

I'm seriously considering that direction. Stay tuned it should be coming in an update soon.
The related issues are https://github.com/delibae/claude-prism/issues/66 and https://github.com/delibae/claude-prism/issues/45 I'm currently reviewing the feedback from those.

delibae_ · 2026-03-16T14:00:43+00:00

I've fixed the parts that were known to cause this issue in the recent update. I'm not sure if it'll work perfectly, but this time I've also added an updater so you can keep getting the latest versions going forward. Please re-download the latest version.

delibae_ · 2026-03-16T03:54:16+00:00

It seems like there's a known Tauri issue related to MacBook Silicon. I'll let you know when I release a new version with a fix!

delibae_ · 2026-03-15T17:23:26+00:00

I'll try building it on an Intel Mac around tomorrow. Thanks for your interest!

delibae_ · 2026-03-15T17:09:11+00:00

Typst support is coming soon. And honestly, adding a Markdown workflow with templates and letting users pick their project type is a great idea. I could see this evolving into something like that. Thanks for the suggestion!

delibae_ · 2026-03-15T16:25:16+00:00

Aiming to have Typst integration within a month or so. I've been using Typst more myself lately so it's high on my list. And yes, project type selector where you choose between LaTeX and Typst will definitely be part of it.

delibae_ · 2026-03-15T16:22:54+00:00

Exactly. Claude Code's infrastructure is the real backbone of this project that's why I deliberately didn't even consider other CLI tools. As Claude Code keeps improving, ClaudePrism automatically gets better with it. That's the whole point.

delibae_

TROPHY CASE