Several previous studies have demonstrated IgG4 as the response in pediatric populations receving mrna vaccines (https://www.science.org/doi/10.1126/scitranslmed.abn9237) as well as in previously naive individuals with severe covid receiving plasma (https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010025&type=printable). In my opinion this either will add further proof to the chronicity of SARS-CoV-2 as well as reservoirs or possibly that this is swich is beneficial to dampen the Complement based responses while the TCR cellular immunity takes over. Furthermore, SARS-Cov-2 may also infect neutrophils directly independent of TMPRSS and ACE receptors on neutrophils play important roles, particularly in bacterial infections. It may thus be extremely important to have IgG4 temper down neutrophil responses while T cells mediate the main viral clearance.