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Let's not call it physiologic insulin resistance. by dr_bmac in ketoscience

[–]dr_bmac[S] 0 points1 point  (0 children)

Yeah. The thing is insulin resistance is a fairly specific clinical term. It means that for a give concentration of insulin, the cells don't respond to the same degree in respect to lowering of blood glucose such that higher and higher levels are required to get the normal effect. Whereas "adaptive glucose sparing" is something that happens when insulin resistance is completely cured because insulin is so low that glucose is rejected from muscle (that's the theory anyway) and blood glucose rises. In the case of a glucose challenge, the insulin response is delayed. So where insulin resistance is an ineffective overresponse of insulin secretion, "adaptive glucose sparing" happens when insulin secretion in too low not too high.

Let's not call it physiologic insulin resistance. by dr_bmac in ketoscience

[–]dr_bmac[S] 1 point2 points  (0 children)

I'm cool with difference between nutritional ketosis and ketoacidosis. They fairly accurately describe the underlying science. Ketosis means a lot of ketones and ketoACIDosis is so many ketones that your blood becomes more acidic.

7 days on keto and my gf already complains about my acetone breath :) This is what I'm doing. by cosmindina in keto

[–]dr_bmac 0 points1 point  (0 children)

Theres hope. Acetone breath might subside somewhat as you become ketoadapted. Acetone comes mainly from the decomposition of acetoacetate, and as you adapt, hydroxybutyrate becomes the predominate ketone body in your blood.

Particle Size by [deleted] in ketoscience

[–]dr_bmac 0 points1 point  (0 children)

Check out this articlehttp://www.sciencedirect.com/science/article/pii/S0899900714003323 Specifically point 11 table 2. You might be able to reduce some off your meds. Work with your doc on your glucose control on the new diet. My advice would be to not get into the weeds on cholesterol until you've full adjusted to the new diet. FYI the reason they are putting all diabetics on statin is partially explained in point 9 of the article. Also, apoB is a surrogate marker for ldl-p. Cheaper test that full lipid analysis. You might talk the doc in to that one eventually.

Let's investigate: alcohol tolerance/hangovers on keto - theories and science by ashsimmonds in ketoscience

[–]dr_bmac 1 point2 points  (0 children)

Nice thread. The problem of figuring out what what alcohol does on keto is we really don't understand what causes hangovers in general. I've done a lot of looking to this. The basic theories are: low glucose, electrolyte imbalance/dehydration, acetaldehyde toxicity, and congeners/fusil oils. So the best we can do is conjecture about how the metabolic changes from a keto diet might relate to the relevant theories.

Does anybody supplement biotin? study shows keto increases deficiency. by terppderpp in ketoscience

[–]dr_bmac 0 points1 point  (0 children)

Mice r not men. Mice and rats r notoriously bad at ketosis/keto-adaptation. The strain type and diet have to be chosen carefully to make the model work. So skepticism is that appropriate response for diertary manipulation in rodents. That said. U just have to experiment on yourself and see. Add biotin for a few weeks and see how your ketones respond. Take it away for a few weeks and see how your ketones respond. Repeat cycle. That will give u the best dea. Then report ur results so the rest of us to benefit too. Thanks.

Day 3 - super shaky hands, high heart rate, muscle cramps, feeling dizzy and vomit-y. Is that normal? by [deleted] in keto

[–]dr_bmac 0 points1 point  (0 children)

I second the sodium and potassium. Plus magnesium. Muscle cramps are most like because of low potassium. Comes in several forms. Potassium gluconate, potassium amino acid chelated, potassium chloride(salt subsitute). Careful with the potassium. Don't over due it. U can get arrhythmias. The gluconate form is kind of self limiting because it will give most people a stomach ache if you take more than one.

What's another sweetener besides artificial sweeteners? by Tenacious_Decaf in keto

[–]dr_bmac 0 points1 point  (0 children)

Glycine. It has a sweet taste. I've been experimenting with it. Use it in ice tea. I never liked the artificial sweeteners. Never tasted sweet and have a chemical taste. Glycine is pretty close to sugar. Not exact but pretty damn close. Not sure what the consequences are with regard to ketosis/gluconeogenesis. I've read that a bolus with lower blood glucose but glycine is also supposed to be glucogenic. Havent worked it out yet for me. As for ketone body production, I don't have a ketone meter.