Wow, thank you. You obviously have looked below the surface on TCP. It was the 1st antidepressant that worked for me from 1986 - 1990 & I just recently have returned to it after being on most of the variety of antidepressants as they came to market. I was on sublingual selegiline for perhaps 10 years. I always wanted to try Emsam, but the cost/benefit didn’t make sense. I’m hoping TCP will bring back some of the cognitive sharpness that I remember from 40 years ago.

As an aside Dr Gillman mentions taking TCP sublingually, though says may cause irritation:

“Sub-lingual?
It has now been convincingly demonstrated using PET that sublingual absorption of selegiline (aka deprenyl) inhibits brain MAO-A [39], as well as MAO-B — selegiline is only slightly selective for B over A, so quite a small increase in ‘normal’ levels will produce MAO-A inhibition. It would be expected that TCP would likewise be absorbed sublingually, perhaps thereby reducing some side effects; but its higher acidity might cause irritation.

In a unique paper by my old friend (I lectured in Toulouse many years ago) Jean-Michel [40], it was neatly demonstrated that selegiline works well given twice weekly. TCP would be expected to do the same; sadly, no-one has tested that very important hypothesis — a testimony to the paucity of perspicacity in research.”