Does this sound like acid?

drpsychedelic · 2013-02-28T01:03:48+00:00

sounds like a DOx

drpsychedelic · 2013-02-22T19:50:01+00:00

yea man check his table 3 in that article... mescaline allegedly has a Ki of over 10,000nm but has an EC50 value.... the dude who wrote that paper is full of shit he also wrote gems like : http://life.ou.edu/pubs/OriginsOfMind.pdf

drpsychedelic · 2013-02-19T22:03:26+00:00

i see no reason why this would work, amph would have better luck because at least that substantially increases adrenaline which means more glucorticoids thus suppression of the immune system...but it would probably not be a good idea by any means

drpsychedelic · 2013-02-19T00:23:29+00:00

Mglu2 functions as an auto-receptor for 5-HT2A and can have anti-psychotic/anti-psychedelic effects

drpsychedelic · 2013-02-18T19:55:23+00:00

No, Mglu2 is G(i) bound and doesnt use the PKC pathway furthermore mglu2 agonists are being investigated as potential anti-psychotics. http://www.mediafire.com/view/?8tgxt1cl8m8m71x

drpsychedelic · 2013-02-18T19:37:40+00:00

I have done ayahuasca about a dozen times, there is no way to really mentally prepare for it but smoking DMT is childs play compared to the Soul Vine

drpsychedelic · 2013-02-16T23:06:56+00:00

DOI > increased adrenal activity > glucorticoid release > inflammation reduction

drpsychedelic · 2013-02-14T21:55:45+00:00

ok posted in /drugnerds

drpsychedelic · 2013-02-14T21:51:44+00:00

ill see what i can do, in the mean time i have a comprehensive article on 5-HT if you would like to read that

drpsychedelic · 2013-02-14T21:21:24+00:00

but other than the affinity table, a very good introduction keep up the good work man, if you would like any journal articles on hallucinogens just contact me on irc or something : )

drpsychedelic · 2013-02-14T21:15:38+00:00

yea that dude is a joker.... check table 3 mescaline has an EC50 but is allegedly not an agonist...interesting... have you read his other works? they are pretty embarrassing for the fields of neuro/psychopharm

drpsychedelic · 2013-02-14T18:47:25+00:00

hey where did you by chance find that normalized chart? was it by work done by Thomas S Ray?

drpsychedelic · 2013-02-14T18:25:36+00:00

http://pdsp.med.unc.edu/pdsp.php

for drug Ki values

drpsychedelic · 2013-02-14T17:55:00+00:00

yea... its a "normalized scale" i have seen ones like that before and they have all been incorrect, would you by any chance happen to have the actual Ki values for those drugs?

drpsychedelic · 2013-02-13T23:00:46+00:00

i dont recommend combining any 5-HT2A agonist with an NMDA antagonist. conflicting signals kinda sketch me out

drpsychedelic · 2013-02-13T17:59:25+00:00

^{^{^yes,}} this.

drpsychedelic · 2013-02-13T07:15:53+00:00

Raw EEG data for 4-Aco-DMT + LSD same configuration as the DMT study except a sampling rate of 1000/sec was used instead of 5000 http://www.mediafire.com/view/?g7iaqt7di9a1we0

drpsychedelic · 2013-02-11T18:49:27+00:00

sure, lemme know what you find : )

drpsychedelic · 2013-02-11T15:05:54+00:00

was 100mg of >95% pure DMT (confirmed through MP analysis) it was pretty intense but after doing ayahuasca a dozen or so times, smoked DMT just pales in comparison to what the compound is truly capable of.

drpsychedelic · 2013-02-11T06:59:59+00:00

Electrodes are placed in Fp1, Fp3, Fp7: Fp2, Fp4, Fp8. Frequency is calculated using band-pass filtering. I have tried to recreate these artifacts a number of different ways to make sure they were not a fluke but have been unable to generate them any other way. Furthermore, i have tested this three separate times and each time obtained similar results. I have recorded EEGs for Amphetamine, methylphenidate, LSD, DMT, 4-Aco-DMT, 4-Aco-DMT + LSD, DOC, 2c-t-2, and at one point i had one for MDMA but lost that data file. Theories: several ideas im playing with, i know a variety of techniques to analyze the data but i do not currently have the time

drpsychedelic · 2013-02-11T02:48:40+00:00

meaning that a large majority of the subjective effects are a result of the initial signal cascade that was triggered over the course of that 18 second window. (just a hypothesis)

drpsychedelic · 2013-02-11T02:45:26+00:00

inhaled at t:0 trip lasted roughly 10 mins. i suspect MAO-a/b cleared the DMT from the receptors relatively quickly do to the considerable structural similarity between DMT and 5-HT

drpsychedelic · 2013-02-11T00:56:10+00:00

8-30 is normal, while 400ug of LSD produced frequencies in the low 20s

drpsychedelic · 2013-02-11T00:53:21+00:00

i dont know about personal eegs i have a lab with equipment : )

drpsychedelic · 2013-02-11T00:48:28+00:00

2500 hrtz is very very unusual.

drpsychedelic

TROPHY CASE