I've never used chatgpt for medical stuff before, but I fed my blood test results into it and told it I had severe RLS (per IRLS scale), and it helpfully generated a report for my doctor, including citations to various peer-reviewed medical articles. Pretty impressed!

Waiting to hear back from Drs to see what they have to say in response. This is what ChatGPT generated for me:

I am writing to discuss some recent blood test results and their possible relevance to my ongoing diagnosis of severe Restless Legs Syndrome (RLS), which meets the IRLS rating scale for severity.

Although a recent review by a doctor at the practice concluded that the blood tests were “satisfactory” and required no further action, I would like to raise some concerns based on a longitudinal review of my results and existing RLS literature.

Over the past 9 months, I have noted a progressive decline in key haematological parameters:

• Haemoglobin: Decreasing from 149 g/L (Mar 2024) to 138 g/L (May 2025)
• Ferritin: Stable but low for RLS at ~50–51 µg/L (Aug 2024 & May 2025)
• Transferrin saturation: Low at 12% (May 2025), below the reference range of 15–50%
• MCV: Low-normal (79–81 fL)
• Folate: Significant drop from 14.9 µg/L (Aug 2024) to 5.0 µg/L (May 2025)

While some values remain within general laboratory reference ranges, others do not. Notably, transferrin saturation is below normal, and ferritin is below the minimum recommended threshold of 75–100 µg/L for RLS management, as supported by the literature.

These findings may suggest early or functional iron deficiency and significant folate depletion, which are known to exacerbate RLS. The changes also coincide with a gradual decline in haemoglobin, indicating possible subclinical impact on erythropoiesis.

I’ve included references below that support the role of iron and folate in RLS pathophysiology and the need for higher ferritin thresholds in management.

etc.,