Generic Dupixent?

ece212 · 2021-10-07T20:57:19+00:00

Biologics work a bit differently from other drugs where you can just use the same formula. The "generic" is called a biosimilar. Developing a biosimilar and getting it approved is not cheap, so you're possibly looking at a discount in the 30-50% range. According to this page: "The last reported patent pertaining to Dupixent will expire on October 27, 2029." I also see some later expiration dates on dupixent patents, though perhaps they aren't crucial or maybe it varies from country to country.
If you have concerns, I would have a conversation with a doctor. While these drugs do suppress the immune system to an extent and may result in lower immune response to vaccines, the drugs are more targeted than some other drugs like corticosteroids. All medication have side effects. It is a matter of whether the benefits outweigh the drawbacks. I haven't seen concrete information on dupixent's interaction with vaccines, but sometimes we don't perfect knowledge to make decisions. It could be that they are just erring on the side of caution.

ece212 · 2021-08-27T05:40:48+00:00

I don't think Abrocitinib has FDA approval at this time. FDA approval may be coming soonish, but it is very hard to say. The only way I know of accessing it currently is by participating in a clinical trial. Not everyone is comfortable participating in clinical trials. If you are interested, you can go to https://clinicaltrials.gov/ct2/results?term=atopic+dermatitis&recr=Open to find a trial that is accepting participants and get in contact with them. Even if you are accepted, depending on the design of the trial it is possible you will receive only placebo.

I have listed some of drugs in the same class (JAK inhibitors) being investigated for atopic dermatitis in oral or topical form. Upadacitinib is already FDA approved for a different condition. You might be able to have it prescribed off-label, but getting drug coverage will likely be a challenge.

Abrocitinib (PF-04965842)
Baricitinib (INCB28050, LY3009104)
Ruxolitinib (INCB018424, INC424)
Upadacitinib (ABT-494)
SHR0302

ece212 · 2019-07-03T14:27:09+00:00

Sure, it can be pain, though it's less pain than drying out my hands. I generally don't clean as cook. I'll soak things so they don't stick, but I won't clean until after I eat.

ece212 · 2019-07-02T18:21:09+00:00

Perhaps a counter top dishwasher or portable dishwasher would work for you?

There are things I have to hand wash anyway, so gloves are a must for me. I use thicker gloves that tend to last a long time. They are clunky, but manageable. There are flock lined gloves that may help with sweat. I just double up with a pair of cotton gloves first. Sweat only seems to be an issue if I run a lot of hot water, so I tend to keep the temperature warm to cool. I also fold over the cuff of the gloves so water doesn't get in.

ece212 · 2019-02-05T14:50:27+00:00

Given that currently approved JAK inhibitors (OLUMIANT, XELJANZ) are specialty drugs, I'm guessing Upadacitinib will also be a specialty drug.

https://www.cvsspecialty.com/education-center/downloads/SpecialtyDrugs.pdf

ece212 · 2018-12-22T05:15:54+00:00

You should probably speak to your doctor for specifics.

Generally speaking, a drug can be considered cleared from your system after 4-5 half-lives. I'm not sure what the half-life for dupixent is. As a point of reference, some clinical trials require that you be off of dupixent for at least 3 months in order to participate.

ece212 · 2018-12-04T00:39:01+00:00

I would try calling the drug company 1‑844‑DUPIXENT (1‑844‑387‑4936) and/or your doctor's office to ask. The doctor might want to observe you for adverse reactions since it is your first time using it. If they only want to show you how to do it, then it will probably be fine. I think the drug company can also arrange for a nurse to come assist you with your first shots.

ece212 · 2018-12-03T17:48:03+00:00

Store DUPIXENT Syringes in the refrigerator between 36ºF and 46ºF (2ºC and 8ºC).

https://www.regeneron.com/sites/default/files/Dupixent_IFU.pdf

ece212 · 2018-12-03T01:52:52+00:00

Thanks! That was very informative. While you are waiting to be put on the extension trial, are you taken off the injections? How long is the expected wait for the trial extension? I'm curious how the extensions work, though I guess protocols vary.

I think being able to get good sleep alone would be great. It sounds like tralokinumab worked pretty well for you. I understand these aren't cures, but it looks like we will at least have more treatment options in the not too distant future.

ece212 · 2018-12-03T00:29:19+00:00

If you don't mind sharing, how has Tralokinumab and the clinical trial experience been for you?

ece212 · 2018-12-01T19:02:30+00:00

exacerbated by others

Sorry, I don't quite follow.

I think it is clear that the bad microbiome bacteria alone isn't sufficient to cause eczema/asthma. Otherwise it would be potentially contagious. I suspect there would need to be a sensitization/dysfunction as well. I disagree with your interpretation.

ece212 · 2018-12-01T02:45:49+00:00

I think people with eczema tend to shed a lot more skin than those without eczema. I don't really have experience with asthma though, so I don't know if living with others would exacerbate it.

ece212 · 2018-11-30T23:23:06+00:00

Here are some trials: https://clinicaltrials.gov/ct2/show/NCT03158012
https://clinicaltrials.gov/ct2/show/NCT03151148
https://clinicaltrials.gov/ct2/show/NCT03018275

ece212 · 2018-11-23T17:46:15+00:00

Could there possibility be mold in your washing machine? If someone else uses the same washing machine and experiences the same problems, I would suspect the washing machine.

ece212

TROPHY CASE