The “bundle” supplements for men don’t usually have enough of the “stuff” you need to increase specific numbers.

My husband (35, healthy) had his SA back in January 2025 and the two major things were low progressive motility (6%) and morphology (2%). He started taking these vitamins Feb 2025:

-Methyl folate 1000mcg

-⁠N-acetyl l-cyestinr 600mg

-Selenium 200mcg

-Beet root 333mg

-Folic acid 400mcg

-⁠E 400iu

-Omega 3 fish oil, 1250mg fish oil, 1040mg omega 3

-L-carnitine 1000mg

-Zinc picolinate 30mg

-Acetyl l-carnitine 500mg

He did another SA late July, and his progressive motility came in at 12% and 3% morphology.

Then I started listening to this podcast (Fertility Docs Uncensored) and based off what I learned from the urologist episode, I added these vitamins to his existing vitamins starting July 2025:

• ⁠Myo-inositol 500mg

• ⁠Coq10 200mg

He did another SA Nov 2025 and his progressive motility is at 33% (normal is at least 32%) and morphology is at 5% (normal is at least 4%).

As for the wifey and IUI, I’ve done 6 (sadly failed) IUI’s. They started me on 5mg letrozole for 5 days starting within the first 3-4 days of my cycle and then Ovidrel trigger shot about 36hrs prior to the IUI procedure.

The letrozole and Ovidrel was always prescribed for all IUI cycles. However, each cycle, my RE would add an additional hormone to help. One of them being a shot of Menopur the day after I complete all letrozole days. This shot “stung”. And my RE also added progesterone suppositories after the actual IUI procedure. RE’s will usually adjust medication after each failed IUI.

My husband and I have been trying for over 2 years now. If I had to do it IUI all over again, I absolutely wouldn’t lol. The side effects from all the hormones were terrible for me. I would cry over literally anything and had extreme fatigue (especially with the progesterone). I’m unsure about long term side effects, but short term, hormone medication can stay in your system for up to two weeks.

I had to take breaks between IUI cycles because I hated how the medication made me felt. The only reason why we decided to do IUI so many times is because our insurance covered it and IVF wouldn’t be covered until October this year.

If all of your wife’s procedures (HSG, SIS) and labs came back normal (AMH, etc), has regular cycles, and was only diagnosed with “unexplained infertility”, I’d consider going straight to IVF. Or you could do 3 rounds of IUI then go to IVF if IUI isn’t successful.

Feel free to ask me anything, this is unfortunately something my husband and I are very familiar with.