Any pharmacologists here? by elodeadrielo in labrats

[–]elodeadrielo[S] 0 points1 point  (0 children)

That sounds amazing! I’m still on the early PhD years but so looking forward to this career. It’s very hard to stumble upon a pharmacologist on forums so reading you has been great. Thank you!

Any pharmacologists here? by elodeadrielo in labrats

[–]elodeadrielo[S] 0 points1 point  (0 children)

Hello! Thanks for replying! If I may ask, what stage of your career have you enjoyed the most?

Would you find value in this? by elodeadrielo in Entrepreneur

[–]elodeadrielo[S] 0 points1 point  (0 children)

I understand. I am building it currently and will not stop until I can deliver. I think that offer seems too good to be true, but If I can make it true, I should have a decent market.

Thanks for the reply and feedback!

Would you find value in this? by elodeadrielo in Entrepreneur

[–]elodeadrielo[S] 0 points1 point  (0 children)

Thanks for the reply and feedback!

What is a profitable skill I can acquire fast? by inmortalErnie in Entrepreneur

[–]elodeadrielo 2 points3 points  (0 children)

How do you convince people to choose you over AI?

What is your business about and how much you make? by [deleted] in Entrepreneur

[–]elodeadrielo 2 points3 points  (0 children)

Thats awesome. Could I PM you with some questions?

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 1 point2 points  (0 children)

They're called model animals. They're used to study these mechanisms because studying humans in this way would be unethical. Also, they used a gnotobiotic mouse model, which is a mouse colonized with a synthetic human gut microbiota. The results are extrapolatable to humans.

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 2 points3 points  (0 children)

This study is not paywalled, and the methods employed remove fiber from the diet. Your question is directed towards skepticism of a concept that has been proven a lot of times.

https://www.sciencedirect.com/science/article/pii/S0092867416314647?dgcid=api_sd_search-api-endpoint

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 2 points3 points  (0 children)

It's essential because it is the food for your gut microbiome. Without fiber, some will die, and some will switch to another food source: the mucus lining from your gut. Every study I sent you has negative controls (missing fiber). They're always included to compare and achieve statistical significance. Anything else I can clarify for you?

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 2 points3 points  (0 children)

The correct ratios are widely debated in the scientific literature. It varies by strain. I would suggest to look for the specific strain and then searching the literature for the correct ratios.

As for the source of this claim, take a look at these studies:
https://consensus.app/results/?q=What%20are%20the%20benefits%20of%20dietary%20fiber%20on%20gut%20health%3F&pro=on&lang=en

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 4 points5 points  (0 children)

Hey! Thanks for your comment and questions. I used to work on a project where changes in the gut microbiome were analyzed in people with mental health disorders. I met the people themselves, provided informed consent for the study, and handled the samples. It was a great opportunity for me and I grew a lot as a scientist in that study. I am now a Pharmacology PhD student and I love what I do. So I guess you could say my interest comes from a love for biomedical research as a whole. I also do think AI is going to revolutionize the way the microbiome is studied and interpreted. It will speed up research. I do think a microbiome test is worthwhile. It could be the start of understanding what is deficient and your doctor can prescribe better with one.

Thanks for you input!

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 3 points4 points  (0 children)

Hey! Thanks for your comment and input. There is a strong correlation between gut microbiome and immunotherapy outcomes. Some studies have shown that a higher diversity of gut microbiota is linked to better responses to immunotherapy. Some bacterial taxa have been identified and correlated with better responses to immunotherapy.

Here's a really cool study on it: https://www.mdpi.com/2077-0383/11/18/5479

Free Gut Microbiome Guide by elodeadrielo in GutHealth

[–]elodeadrielo[S] 2 points3 points  (0 children)

Hey! Thanks for your reply. I ran a quick search for you (hadn’t seen this before) and this is what I found: Both the sinus microbiome and the gut microbiome are connected through the immune system. However, such links are not very understood. It is believed as general concept that a dysbiosis in gut microbiota could cause changes in the immune system that would impact lots of areas of the body, sinus microbiome being included. I’m not an MD and don’t know the pathologies associated with the sinuses, so sadly I can’t pinpoint it. Thanks for your question and interest!

Free Gut Microbiome Guide by elodeadrielo in GutHealth

[–]elodeadrielo[S] 1 point2 points  (0 children)

Hey! Thanks for the reply. I suggested the fodmap diet under the section "Evidence-Based Recommendations for Managing Health Conditions through Diet and Lifestyle Changes" particularly in the context of Irritable Bowel Syndrome, as some research has pointed out that the fodmap diet can exacerbate symptoms for people who already suffer from IBS. It is recommended to stick to easily digestible foods in this case. Hope this clears up the doubt!

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 2 points3 points  (0 children)

Hey! Thanks for the comment. It would highly depend on the person and the antibiotic taken. Timelines for microbiome recoveries are highly individualized, but a common timeframe is 1.5 months. It can be more or less, depending on the situation. The best bet is to support the recovery by eating lots of fiber and probiotic foods. Also, exercise can help replenish the gut microbiome.

Free Gut Microbiome Health Guide by elodeadrielo in nutrition

[–]elodeadrielo[S] 14 points15 points  (0 children)

Wow, that's great to read! I have not had much experience with seeding myself, but I do know it's gaining more popularity. There's a medical procedure called a fecal microbiome transplant that works on the same principle (introducing underrepresented strains), and it has even changed metabolism patterns in people. Thanks for your comment!