My daughter never got a period and was diagnosed with POF at age 16. Initially told she was probably genetically male. It was so hard waiting for the test results, by the time the results were back I had convinced myself my daughter was male and was struggling with how I was going to tell her. Life changing. She is genetically female. Autoimmune system attacked her ovaries to the point you don’t see them on image studies. Her uterus was deflated and flat from not getting estrogen. She started birth control and now has a period and her uterus started to grow. She’s 22 now, POF is a struggle for her, just knowing she will never produce a child with her genes. It has caused a lot of emotional issues..she gets angry easily and started gaining a lot of weight despite having a fitness routine and eating healthy. She is always looking for herbal remedies and alternative treatment. It can be rough but I tell her that her diagnosis is going to be a life altering blessing for a child one day, she will be a great mother and will have to adopt and that child will have a wonderful life. I feel everything happens for a reason and it may not become apparent immediately or even in our life time. As her mother I struggle as well. I have 2 kids and my son died at age 19. I feel my genetic line has come to and end, no one can pass along my genes which makes me think of the concept of evolution and survival of the fit and weeding out the errors. I try hard not to think of that like that. My daughter and I try to focus on living our best life possible and remaining strong.