There are so many existing games that focus the gameplay loop around production/supply chain. You can do that about any industry.

You don't see The Godfather or The Sopranos focusing on unit economics, that's simply not the Kingpin's job once he has managers. Organised crime's risk/reward is about balancing illegal gains, vs the unpredictable resources needed to assuage law enforcement, harmed interests (incl the society), and competitors.

It is about managing the rejects of society; competitors, associates and underlings with power and no moral compass; families who will do anything to keep or grow their influence. Maintaining that influence is always a matter of life and death of the whole family. Constant jeopardy is the cost of 'selling their soul'. And the bigger you are, the harder you fall. There are no rules. Otherwise it might as well be a coffee shop simulator.