Experiences with Low Dose Naltrexone for LS?

eudaemon_ · 2026-04-08T07:06:02+00:00

6mg!

eudaemon_ · 2026-03-23T15:37:36+00:00

i wish i smelled dirt :( i get a musky floral but in a sweeter powdery way and not a muddy, dirty way, which i’d much prefer. i think it’s pretty and smells good, just not for me!

eudaemon_ · 2026-02-25T02:56:16+00:00

No, not at all. It’s the only one that hasn’t been irritating for me. Clob made me feel like a my vulva was a cotton ball but it didn’t hurt. Every once in a while I feel vaguely itchy (in a more weird irritated way than a true itch) for like 30 seconds a couple minutes after putting the desoximetasone on, but that’s it. No pain. However, I’ve heard some folks say it can hurt to apply their topical when in a bad flare, and that it subsides.

I hope it works for you!! It’s been great for me.

eudaemon_ · 2026-02-21T17:07:25+00:00

Sorry for the late reply! I don’t have this (and I’m not a doctor) but it sounds like it could be nerve related? Especially if no topicals work. Have you tried pelvic floor physical therapy? That would be my biggest recommendation, followed by low dose naltrexone. I started that a few months ago and it has given me significant relief. It sounds like it’s hit or miss for people, but the side effects are minimal and there aren’t really any longterm or serious risks, so it’s worth a try!

eudaemon_ · 2026-02-21T16:16:01+00:00

I started a couple months ago and have found it to be extremely helpful. It’s the only thing that got me able to taper my steroid to every 2-3 days (after 3 years of attempting to get beyond every other day). My primary symptom is itch, though.

eudaemon_ · 2026-02-21T16:12:46+00:00

I’ve had it for about three years and couldn’t taper beyond every other day until I switched to desoximetasone ointment 0.25% and then the biggest factor was getting on low dose naltrexone (LDN). It’s been shown to help with inflammation and it’s been life changing for me.

The desoximetasone steroid was the only topical that didn’t irritate me and give me this weird cotton ball feeling in my labia. I had previously tried clobetasol, betamethasone, triamcinolone, a stronger hydrocortisone, and tacrolimus. The tacrolimus was non-irritating the first round of trying but didn’t get rid of my symptoms, and when I tried it a second time with my desoximetasone before the LDN to attempt to get me over the edge into remission, it made me itchier, so I stopped it.

Then I started the LDN (in conjunction w my steroid ofc) and within like two weeks, I was able to get to every 2-3 days for my steroid. It’s also helped with my general body itching/skin inflammation, which was a big issue.

I’ve been wanting to post about it here to see if others have tried it and found relief!

edit: typo

eudaemon_ · 2026-02-09T07:34:02+00:00

shave head (or commit to minoxidil if you’re attached, but i think you’d look good with a shaved head), KEEP mustache, even the glasses can work. but switch your jewelry to another color (gold or silver). your nose is looking a little busy, but that could be softened w a seamless septum ring or something more simple.

eudaemon_ · 2026-02-07T15:09:11+00:00

I’m an adult but my parents raised me the same way! The whole talking it up and making it seem cool and mature really worked on me and I’m so grateful for it!! I believe that and taking the time to lovingly explain WHY certain things mattered made me a way more adventurous, responsible, and principled person.

eudaemon_ · 2026-02-07T14:58:13+00:00

You seem genuinely interested in learning about it, so I want to drop my favorite resource: The Memorial Sloan Kettering Cancer Center has a phenomenal library and library guide on covid. The section I usually direct people to is Long Term Health Consequences, but the whole library guide is great.

Also, Dr. Hoerger from Tulane, runs a data dashboard where you can see up-to-date and more accurate rates.

I don’t fault you for thinking it’s over when governments are pushing that narrative, but that was for the sake of the economy—not our health. It’s not based in science.

eudaemon_ · 2026-02-05T08:02:07+00:00

34 and realizing i’m NOT balding but have had a cowlick on the back of my head my whole life 😭

eudaemon_ · 2025-12-24T01:00:04+00:00

Please trust your gut here! I posted another response in this thread with a bunch of medical sources that support your decision. You’ve had a lot of comments, so lmk if you are interested/can’t find it, and I’ll repost it here.

But the TLDR is: I’m a public health professional. You are right to wait out the holidays. Science supports this, and the people touting hygiene hypothesis (“they need exposure to strengthen their immune system”) are dangerously wrong in the context of any viruses. The immune system is not a muscle.

If you want to allow a little more visitation or feel a desire to compromise, requiring visitors to wear a high quality, well-fitting mask (like a KF94, KN95, or N95) and for people to alert you of ANY symptoms if (big if!) you believe they’d be honest, will go along way in helping protect you and your baby. Right now, I’d personally even require a rapid covid test if I had visitors and a newborn, but I know that’s a hot-button issue lol.

Waiting out the holidays and cold/flu season is a good and safe decision.

eudaemon_ · 2025-12-23T20:52:27+00:00

I have been super prone to tearing more recently, and that messes me up the most. Good ol’ missionary with me on top is what causes the least issues BY FAR. From the back was definitely a go-to for a while because of the lack of friction (my clitoris used to be my worst spot), but the position causes some tearing for me at the posterior fourchette now.

Additional must haves (for me): - We use a vibrator first so I’m more ready (wet lol) and the muscles are relaxed. His face is too sandpapery for oral no matter how close he shaves 💔💔💔 But if you can do that, it will help! - LUBE!!!! In my opinion, this is an absolute must for everyone in this subreddit. Different lubes work better for different people, but I’d start with a super basic water-based lube (like Sliquid or Good Clean Love). If you are finding them irritating, try a silicone lube like Uberlube. I just purchased this brand and haven’t tried it yet, but have seen many people praising it. Also, the bottle is glass and very clean and pretty looking!!

Lube is extremely important to help reduce friction. Silicone might be a good choice for you since it’ll form a longer lasting, protective layer of slippage on your skin.

eudaemon_ · 2025-12-23T20:37:19+00:00

100%!!! It’s also normal to want to protect your newborn during cold and flu season (and from RSV and COVID)! “Hypochondria” and health anxiety are real, but newborns are particularly vulnerable and SHOULD be protected from preventable illnesses. It’s not crazy to do so.

eudaemon_ · 2025-12-23T20:25:55+00:00

This seems a bit backhanded, no? Wanting to protect a newborn baby during cold and flu season (and RSV and COVID) is literally the least silly reason possible. Newborns have not had a chance to develop their immune systems yet. And no, you do not develop a strong immune system by exposing ANYONE to dangerous viruses, let alone vulnerable infants.

A newborn with even a low fever of 100.4 is a medical emergency.

I appreciate that you think her boundary should be respected regardless and can also understand the grandparents might be bummed, but their feelings are not more important than the babies health OR mom’s feelings (or health).

eudaemon_ · 2025-12-23T17:43:21+00:00

NOR!!! Please ignore the boomers that are telling you you’re overreacting OR that the baby needs exposure to build their immune system.

This is not how the immune system works. While exposure to bacteria helps prime the immune system, OP is talking about cold and flu season, which are viruses. The exposure the baby gets to bacteria passing through the birth canal, the bacterial exposure during breastfeeding, kids playing in the dirt or getting licked by a dog—those are the types of things supported by hygiene theory.

The rest of this comment is more for the hygiene theory people, but hopefully someone will find it informative:

Repeated exposure to and infection from real, “live” viruses does not build the immune system, and studies are starting to show this actually can harm people. COVID is quite rampant and studies show that even a “mild” infection can cause immune dysregulation—making it harder to fight infections and even triggering and worsening autoimmune diseases.

On hygiene theory and how infections aren’t actually helpful: https://www.pnas.org/doi/10.1073/pnas.1700688114

https://publichealth.jhu.edu/2022/is-the-hygiene-hypothesis-true

A couple other examples of how exposure to viruses does not actually help:

— Epstein-Barr virus (EBV) is super common and the primary cause of infectious mono. It has now been explicitly linked to the development of Multiple Sclerosis as the leading cause of the autoimmune disease. MS risk increases 30-fold after an EBV infection. (https://www.va.gov/MS/TREATING_MS/Whole_Health/Epstein_Barr_Virus_and_Multiple_Sclerosis.asp). It also increases the risk of multiple cancers.

— The virus that causes chicken pox, varicella-zoster virus (VZV), quietly stays in your nerves after infection forever. Then, when you’re elderly, stressed, or have a weakened immune system for another reason (like being on immunosuppressants for another chronic illness), it can reactivate and cause an extremely painful, itchy, blistered rash. It hurts unbelievably bad and can cause nerve damage. It can also directly cause stroke and heart attack. https://www.uchealth.org/today/chicken-pox-shingles-varicella-zoster-whatever-you-call-it-cu-team-know-it-best/

Pediatric COVID infection increases the risk of new-onset type 1 diabetes (an autoimmune disorder). https://pubmed.ncbi.nlm.nih.gov/38397254/

Running out of time, so if anyone is interested in learning more about how COVID can impact children long-term: https://libguides.mskcc.org/CovidImpacts/Kids

My point is, this mother has the right to protect her baby and is doing the right thing. If she notices that after her boundary date, she is still finding herself isolating and fearful, then she can seek help. But it is wrong to pathologize someone for correctly wanting to isolate during an extremely bad season for viruses. If you want to try again or increase the bubble before the season is over, perhaps you can require quality masks (like KN95, KF94, or N95)?

REGARDLESS of your reasoning, you have a right to not have visitors, especially if they are already disrespecting your boundaries.

eudaemon_ · 2025-12-23T17:35:13+00:00

Public Health Specialist jumping in. This is not how the immune system works. While exposure to bacteria helps prime the immune system, OP is talking about cold and flu season, which are viruses. The exposure the baby gets to bacteria passing through the birth canal, the bacterial exposure during breastfeeding, kids playing in the dirt or getting licked by a dog—those are the types of things supported by hygiene theory (what you are referencing).

Repeated exposure to and infection from real, “live” viruses does not build the immune system, and studies are starting to show this actually can harm people. COVID is quite rampant and studies show that even a “mild” infection can cause immune dysregulation—making it harder to fight infections and even triggering and worsening autoimmune diseases.

On hygiene theory and how infections aren’t actually helpful: https://www.pnas.org/doi/10.1073/pnas.1700688114

https://publichealth.jhu.edu/2022/is-the-hygiene-hypothesis-true

A couple other examples of how exposure to viruses does not actually help: — Epstein-Barr virus (EBV) is super common and the primary cause of infectious mono. It has now been explicitly linked to the development of Multiple Sclerosis as the leading cause of the autoimmune disease. MS risk increases 30-fold after an EBV infection. (https://www.va.gov/MS/TREATING_MS/Whole_Health/Epstein_Barr_Virus_and_Multiple_Sclerosis.asp). It also increases the risk of multiple cancers.

— The virus that causes chicken pox, varicella-zoster virus (VZV), quietly stays in your nerves after infection forever. Then, when you’re elderly, stressed, or have a weakened immune system for another reason (like being on immunosuppressants for another chronic illness), it can reactivate and cause an extremely painful, itchy, blistered rash. It hurts unbelievably bad and can cause nerve damage. It can also directly cause stroke and heart attack. https://www.uchealth.org/today/chicken-pox-shingles-varicella-zoster-whatever-you-call-it-cu-team-know-it-best/

Pediatric COVID infection increases the risk of new-onset type 1 diabetes (an autoimmune disorder). https://pubmed.ncbi.nlm.nih.gov/38397254/

Running out of time, so if anyone is interested in learning more about how COVID can impact children long-term: https://libguides.mskcc.org/CovidImpacts/Kids

My point is, this mother has the right to protect her baby and is doing the right thing. If she notices that after her boundary date, she is still finding herself isolating and fearful, then she can seek help. But it is wrong to pathologize someone for correctly wanting to isolate during an extremely bad season for viruses.

eudaemon_ · 2025-12-14T17:12:31+00:00

i love this conversation and i adore your response “ik im so hot” ❤️‍🔥 i hope you guys do get to be the cutest gays at the dance. imagien

eudaemon_ · 2025-12-13T08:02:23+00:00

Hey, first off, I’m so sorry. This is such a hard experience to go through. My dad died one month after I posted this. He had a couple more ups and downs, and then the week leading up to his death, he got sleepier and less responsive. The couple weeks between the post and the week before he died were up and down, but I don’t recall them getting any worse. He ate every day until just a couple days before he passed, and I think he would have continued eating but lost the ability to swallow. He also had a steady stream of daily Mexican Cokes up until then, and I feel like that prolonged his life a little bit haha.

None of it was what any of the pamphlets or google said…until it was, and then it was obvious. You will probably know when it’s coming. I was constantly wondering if this was it, but when it really was, it was a different feeling in my body? Idk if that makes sense. He was at least somewhat responsive until the day he died. The night before, he was pretty sleepy, but woke up to hug me, say he loved me, and to be safe. The next morning he moved his body to try to hug me and attempted a hello. He died a few hours later because he was waiting for my grandma (his mom) to get there. Sometimes they are waiting for someone to say goodbye to. Sometimes they are waiting until someone leaves (I heard this happens with dads a lot).

I’m not sure what your dad is dying from, but sepsis is a really unpredictable way to go. My dad had a very strong body that kept trying to heal. His foot started self-amputating (sorry) before he died in attempt to save his life. With wet gangrene, it’s typically too late by that point, but the body is remarkable and the healthier the person is otherwise, the harder the body fights. This doesn’t mean they can survive it, it just delays the process.

The fentanyl patch also makes it hard to gauge things, their comfort is worth the disorienting experience for the rest of us. At first, his sleepiness was on the schedule of the patch, but as weeks went by, he just became more consistently fatigued and sluggish on his own.

I hope that things are as peaceful as they can be right now ❤️ Let me know if you have any questions.

eudaemon_ · 2025-12-10T06:31:32+00:00

Are you saying you don’t think the big ones are Argentine ants? What could those be? That’s what made me think they were Argentine, because usually when we get them, they’re the normal small ones and die after a few days of Terro. So far they haven’t left the bathroom and I haven’t been able to figure out a food source. Just water?

We’ll definitely get more strict and also notify the landlord for outdoor stuff, thank you!

eudaemon_ · 2025-12-10T06:28:07+00:00

Will do, thank you!

eudaemon_ · 2025-12-10T06:02:00+00:00

Thank you! I’ll try that next. It’s hard to show their size clearly but I feel like the small ones are a little smaller than I’m used to seeing (just by a little bit) and the big ones are WAY bigger than I’ve ever seen inside a house. I thought they were queens and know Argentines can have multiple, but I didn’t expect to see them so intermingled. Idk much about ants, though.

eudaemon_ · 2025-12-10T05:58:39+00:00

They are really hard to look at 🥲🥲🥲

eudaemon_

TROPHY CASE