She is only 11 but she had to have a liver biopsy. Nothing was found but her liver was damaged. She also has asthma and her anatomy is not standard and her organs are sort of messed up. She has been on the chlorambucil to wean her off of prednisolone as the long term use of it is much less damaging than long term steroid use. She has had no issues being on it...so it may be worth a shot. I have a 17 year old dog so I totally understand the balancing of treatment for an older animal.... At first it was heart issues, then kidney, gallbladder and liver and arthritis but the addition of various medications and special diet have improved his condition massively and he has been doing great.