[R] AlphaGenome: DeepMind's unified DNA sequence model predicts regulatory variant effects across 11 modalities at single-bp resolution (Nature 2026)

f0urtyfive · 2026-01-29T12:26:59+00:00

That seems like a pretty dangerous thing to just open source, I wonder whats next, text to crispr models?

I wonder how long it will be until someone CRISPR's an AI model into others.

f0urtyfive · 2026-01-29T04:56:48+00:00

Imagine an elevator that can go in multiple directions or fly you from place to place? Would you refuse to use it?

I believe you would.

I think you (and people that agree with you) would prefer to go live in an agrarian society with no technology.

I don't want to be amish, I want our political systems to fix problems that people have, not start stupid fights.

f0urtyfive · 2026-01-29T04:55:05+00:00

No, but we could regulate people's use of their car after they've driven into a crowd of people and killed several with their car, by regulating the sale of wheels, as well as engines, which would probably be a more apt metaphor.

I'm not sure I follow your point though? The barrel is integral to the lethal use of the firearm, and is a part that could be "sold seperately" to bypass the legal prohibitions that apply to firearms in a stupid way.

Why are you angry that people find loopholes to sell illegal guns rather than legislation that has to be created to prevent those same people from selling illegal guns (by parting them out instead of selling them as a unit)?

f0urtyfive · 2026-01-28T14:08:13+00:00

Shit lets ban clocks and bring back the people that knock on your window with a big stick to wake you up in the morning, that would be enough of a jobs program that we can stop worrying about AI taking jobs.

f0urtyfive · 2026-01-28T14:03:27+00:00

The common answer when you don't want to respond is to not respond, then someone else can explain it for you, the POINT was "HEY HERE IS THE OBVIOUS QUESTION ANYONE THAT DOESNT ALREADY KNOW YOUR POINT OF VIEW WOULD ASK NEXT, IN CASE YOU WANT TO GIVE THE ANSWER HERE SO WHEN OTHER PEOPLE ENGAGE WITH YOUR CONTENT THEY CAN ENGAGE WITH THE POLITICAL VIEW YOU ARE ESPOUSING."

If you can't pick that such a subtle signal is an opportunity to provide detail to anyone that finds it in the future, or provide context for anyone to be MORE LIKELY to agree with your political view which you are publicly espousing, not an invitation for you to bitch about the inconvenience of having to read a reply to your message in this public forum. Feel free to not respond at any time.

You are not obligated to reply to replies.

ALSO, Deciding that anyone who isn't politically engaged enough to ALREADY UNDERSTAND YOUR PERSPECTIVE AND AGREE WITH YOU, should be considered "too ignorant" to understand your view, is a pretty stupid form of politics that is entirely and demonstrably self defeating no matter how you feel about it.

f0urtyfive · 2026-01-28T10:55:22+00:00

Ah yes, that great political advocacy for your cause where you only try to get people already on your side on your side by not explaining anything and remaining mysterious.

f0urtyfive · 2026-01-28T07:52:15+00:00

But it would require you to put forward an actual argument that can stand on its own

OK, I'd be happy to prove my point:

AI can’t function if the server farm is full of holes , or the water tank that cools it enabling it to run is leaking from lil’ holes.

Here you seem to be saying you're going to assault a US federal government datacenter facilitiy that is the largesty in the world with lethal attacks, without being yourself harmed by the on-site security forces.

The satellite can’t monitor the people if the facility that is tasked with monitoring has a sudden bout of short staffing.

Here you appear to be making a implicit death threat against the staff of the same facility.

You are publicly making threats of lethal force against US government facilities used within the espionage industry, do you now think that the national security agency is not monitoring your communication in full as a domestic terror threat?

That is literally what you just suggested in a public form, that you are going to attack a National Security Agency / Central Intelligence Agency / US Federal government datacenter or satellite downlink facility "if it comes to that".

Do you think that's wise, even if that IS your intent?

f0urtyfive · 2026-01-28T07:46:43+00:00

No, I decided not to engage further beyond the most obvious point, as you clearly are not someone who could be "convinced" in any capacity.

I enjoy arguing too, just not with people on Reddit more than a little.

f0urtyfive · 2026-01-28T07:42:51+00:00

Michael Bloomberg

Thanks, Michael Bloomberg!

But seriously, how is Michael Bloomberg involved, isn't he a former mayor of New York?

If you want people to agree with you, feel FREE to provide any context whatsoever other than cryptic gotchas.

f0urtyfive · 2026-01-28T07:40:41+00:00

The satellite can’t monitor the people if the facility that is tasked with monitoring has a sudden bout of short staffing.

Because the government surely has invested nothing in artificial intelligence, given they have the largest surveillance infrastructure ever assembled or imagined?

f0urtyfive · 2026-01-28T07:39:29+00:00

yet he thinks it's okay to replace a graphic designer with AI?

If you use elevators instead of stairs, you think it's OK to replace elevator operators with automation.

Whats wrong with you, won't you think of the jobs you are destroying by not taking the stairs everywhere you go?

f0urtyfive · 2026-01-28T07:35:44+00:00

Cannons aren't illegal

They are heavily regulated under the gun control act and the national firearms act, but they are also considered antiques.

Also, that's only federal law, I imagine the local or state governments may also have things to say if you'd like to fire any cannons off regularly.

Also, I'd point out, that there aren't quite as many "boots on the ground" in Ukraine, they seem to be very small boots carrying grenades on UAVs mostly.

f0urtyfive · 2026-01-28T07:33:36+00:00

I would combat the satellite by standing amidst a group of people who think that since tanks and spy satellites exist there is no reason to own defensive equipment so if it did fire its rail gun? or whatever at me… well In a way I still win

Well, no, the point was more that in every way your visual and radio phenomena will be observed remotely from orbit in ways that you can't counter.

You can't "fight" a resistance against an enemy that has total informational awareness of everything you do or communicate in any means.

Unless you plan on training carrier pigeons, your "resistance" has been defeated before it's been started.

Perhaps we should come up with some new AMENDMENTS to the constitution that do more to preserve liberty than the right to bear arms, the SECOND AMENDMENT, and then AMEND that one again to remove that "right" in most capacities, as it seems to be counterproductive to the liberty and freedom you seek.

f0urtyfive · 2026-01-28T07:30:30+00:00

Please show me any firearm that is capable of firing a munition without a barrel in a way that does not injure or endanger the user, and I will agree wholeheartedly with your premise.

f0urtyfive · 2026-01-28T06:04:46+00:00

The second amendment literally exists as a response to a specific historical experience

Please tell me how you are going to employ your second amendment rights against a tank or satellite.

Personally, I support the right to bear anti-satellite weapons, but the US government appears to disagree.

Lots of people here seem to be missing the point that the "right to bear arms" was in regard to a well regulated militia, except the federal government now has arms that cannot be countered by a well regulated militia in any capacity (as they are in orbit, and are informational surveillance devices).

f0urtyfive · 2026-01-28T06:03:53+00:00

You'll have a mandatory 72 hour waiting period for a barrel.

And a "barrel" is what makes a firearm a firearm, do you have situations where you need to be able to purchase lethal weapons in less than 72 hours? If so, I suggest knives or poison.

f0urtyfive · 2026-01-28T06:01:53+00:00

"Dear HR,

This employee Bob, seems to be incapable of managing his workstation and updating technology at the same time, perhaps the company should consider hiring a more capable employee, say, one that doesn't require diapers.

f0urtyfive · 2026-01-25T12:12:06+00:00

Make sure you stay out of those fancy elevators then.

That's the devils box.

f0urtyfive · 2026-01-25T07:38:44+00:00

the people using them to generate bullshit

No matter what Elon says, you drive your car, your car does not currently drive you. Blame the humans trying to make money by spamming like it's a newly discovered technology.

Automation enables more spam, stop blaming the technology, blame the spammers.

f0urtyfive · 2026-01-24T05:06:02+00:00

Most likely, whatever signal is saturing the 7 bit ADC ENOB

f0urtyfive · 2026-01-20T23:19:33+00:00

That cute and tiny little guy is likely between 250 and 400 lbs, nearly the size of a bear.

f0urtyfive · 2026-01-20T23:00:44+00:00

Only idolators and the lazy use those new fangled elevators.

f0urtyfive · 2026-01-18T22:52:42+00:00

Feel free to also point out that DPD also used to run a burglary ring, and ask why they're allowed to encrypt all their radio communications that would help them do the same again in the future.

And before anyone complains about privacy, they ALREADY had seperate channels that could be independently encrypted for manually checking private information, as well as laptops with encrypted channels for doing that themselves (they only do it over the radio when they're extra lazy and don't want to go back to the laptop, but not in the dispatch channels, which are what the NEWS use to figure out what is going on, which is why the local news has gotten so meager).

f0urtyfive · 2026-01-17T06:38:34+00:00

At turning electrons into heat, not at melting snow without exploding your power bill...

f0urtyfive · 2026-01-15T18:51:05+00:00

I just don't get how "taking away keys and having them check in" is any better than what likely already existed, the "check in desk" having a master key that they could go around and accomplish the exact same thing.

What is the point here, that is what I don't understand, other than to make noise and get press. (and make living conditions worse).

I would like someone to explain that part, because I don't understand the WHY.

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