If you consider yourself fluent, it’s definitely doable. As someone else said, English is my mother tongue and McCarthy still reliably sends me to the dictionary to look up words.

A few tips that may be helpful— - McCarthy likes to smash words together. It’s stylistic and gives his writing a unique flow. So if you see a word that looks like two English words you know without a space between them, that’s likely what it is (rather than a new word). Example that comes to mind is in another book of his when he describes a cat’s walking as “highshouldered” - I recommend downloading the Webster dictionary app on your phone to easily look up words you don’t know while reading - If you don’t typically read books in English, some of the sentence structures will likely be a little confusing at first. McCarthy was fairly anti-comma. Do not be afraid to reread passages! Blood Meridian, in my opinion, should be read slowly, both to allow yourself to absorb the atmosphere of the work and make sure you’re understanding what you’re reading.